Basic Science

基础科学

• 批准号: 8820376
• 负责人: Michael S. Caffrey
• 金额: $ 1.75万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8820376
• 关键词: AIDS/HIV problem; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Area; Basic Science; Behavioral; Biochemistry; Cellular biology; Chicago; Clinical; Clinical Virology; Collaborations; County; Development; Educational workshop; Epidemic; Extramural Activities; Feedback; Funding; HIV; Health Services; Illinois; Immunology; Institution; Laboratories; Leadership; Microbiology; Molecular Biology; Molecular Biology Techniques; Molecular Genetics; Postdoctoral Fellow; Principal Investigator; Property; Proteins; Recording of previous events; Research; Resources; Science; Services; Structure; Techniques; Technology; Training; Universities; cooking; cost; cost efficient; drug discovery; experience; graduate student; interest; member; metropolitan; professor; protein purification; quality assurance; structural biology; theories; virology

The overall objective of the Basic Science Core is to enhance HIV/AIDS research by providing state of the art sic science technologies in a cost efficient manner. We will: 1) Provide basic science services, which include those related to molecular biology, biochemistry, immunology and virology. The molecular biology and biochemistry components of the core will be primarily located at UIC in the Research Resources Center, the Center for Structural Biology and the laboratory of the core's director, Michael Caffrey. The immunology component of the core will be primarily located at RUMC in the laboratory of Alan Landay, the D-CFAR Director. The virology component of the core will be primarily located at RUMC in the laboratory of James Bremer, the co-Director of the core. 2) Provide training and advice for the use of these techniques to graduate students, post doctoral associates, and principal investigators. 3) Encourage interaction and collaboration between users of the core. Monthly workshops on the theory and practice of the techniques available in the Basic Science Core will be sponsored. All D-CFAR members and their laboratories will be encouraged to attend. 4) Develop the Basic Science Core of the D-CFAR into a Basic Science Core of a CFAR. The Basic Science Core will strive to adapt to D-CFAR members needs by encouraging feedback on services provided, quality of service, cost of service, and suggested new services. Efforts will be made to expand the number of users. The Basic Science Core will be directed by Dr. Michael Caffrey and will be co-directed by Dr. James Bremer from RUMC. Dr. Caffrey is currently a tenured Associate Professor in the Department of Biochemistry and Molecular Genetics at UIC. His research interests are focused on the structure and function properties of HIV and AIDS-related proteins. He has expertise in wide variety of experimental techniques that are important for HIV/AIDS research including: molecular biology, cell biology, virology, protein purification, protein characterization, drug discovery, and structural biology. Dr. Bremer is a tenured Professor in the Department of Immunology and Microbiology and Director of the Virology Quality Assurance Laboratory at RUMC. His laboratory has extensive experience in the techniques of clinical virology.

基础科学核心的总体目标是通过提供最先进的技术来加强艾滋病毒/艾滋病研究 科学技术以成本效益的方式。我们将：1）提供基础科学服务， 包括与分子生物学、生物化学、免疫学和病毒学有关研究。分子生物学 核心的生物化学组件将主要位于UIC的研究资源中心， 结构生物学中心和核心主任迈克尔·卡夫瑞的实验室。免疫学 堆芯的一个组成部分将主要位于RUMC的Alan Landay实验室，D-CFAR 导演核心的病毒学部分将主要位于RUMC的James实验室 布雷默，核心的联合主任。2)为使用这些技术毕业提供培训和建议 学生、博士后研究员和主要研究者。3)鼓励互动和协作 核心的用户之间。每月举办讲习班，介绍联合国系统现有技术的理论和实践， 基础科学核心将得到赞助。鼓励所有D-CFAR成员及其实验室 参加这个论坛4)将D-CFAR的基础科学核心发展为CFAR的基础科学核心。基本 科学核心将努力适应D-CFAR成员的需要，鼓励对所提供的服务的反馈， 服务质量、服务成本和建议的新服务。将努力扩大 用户.基础科学核心将由Michael Caffrey博士指导，并由James博士共同指导 来自RUMC的布雷默。Caffrey博士目前是一个终身副教授在系 生物化学和分子遗传学。他的研究兴趣集中在结构和功能 HIV和AIDS相关蛋白的特性。他在各种各样的实验技术方面都有专业知识， 对HIV/AIDS研究很重要，包括：分子生物学、细胞生物学、病毒学、蛋白质 纯化、蛋白质表征、药物发现和结构生物学。布雷默博士是终身教授 免疫学和微生物学系教授兼病毒学质量总监 RUMC的保证实验室。他的实验室在临床技术方面有着丰富的经验， 病毒学