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Akt Signaling at the Crossroads of Depression and Addiction

Akt Signaling at the Crossroads of Depression and Addiction
Akt 信号在抑郁和成瘾的十字路口
批准号:
8679536
负责人:
THOMAS F FRANKE
金额:
$20.45万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-11-15 至 2015-06-30
关键词:
1-Phosphatidylinositol 3-KinaseAKT1 geneAddictive BehaviorAddressAffectAgeAnimalsAntipsychotic AgentsAreaAutistic DisorderBasic ScienceBehaviorBehavioralBehavioral ParadigmBiologicalBiological MarkersBrainBreedingCell physiologyCellsChronic stressClinicalClinical TreatmentCocaineCodeComorbidityConsultDecision MakingDevelopmentDisastersDiseaseDopamineDopamine D2 ReceptorDopamine ReceptorDrug usageDry IceEmergency SituationExtinction (Psychology)FloodsFloorFreezingGeneticGenetic ModelsGenetic VariationGenotypeGoalsHealthcareHeart DiseasesHomologous GeneHospitalsHousingHumanInstitutesLaboratoriesLaboratory ResearchLinkLiquid substanceLocationMalignant NeoplasmsMechanicsMediatingMedicalMedical centerMental DepressionModelingMolecularMoodsMotivationMusMutant Strains MiceNeuronsNeurosciencesNew York CityNitrogenPathway interactionsPatient CarePatientsPhasePhosphorylationPhosphotransferasesPlayPlumbingPredispositionProtein-Serine-Threonine KinasesPsychiatryReagentReceptor ActivationReceptor SignalingRecoveryRegulationReportingResearchRewardsRisk AssessmentRisk FactorsRodentRoleSafetySamplingSchizophreniaScienceSerotonin Receptor 5-HT1ASignal PathwaySignal TransductionSiteStressSystemVendoraddictioncongenicdesigndopamine systemdopaminergic neurondrug of abuseexperienceextracellularhospital patient careimprovedinnovationinsightmedical schoolsneuropsychiatrynoveloperationpreferenceprogramspromoterpsychostimulantreceptorrecombinaserepairedresearch studyresponserestorationserotonin receptorsexsocial

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中文摘要
翻译
2012年10月29日,纽约大学朗格尼医学中心经历了一场前所未有的风暴,造成了破坏。 这深深地影响了我们的病人护理、研究和教育设施。NYULMC的应急电源 该系统的设计和建造符合所有安全规范,可承受比最高洪水更高的浪涌 这是纽约市在过去世纪的最高水平。超级风暴桑迪显然超过了这些水平。虽然我们 安全疏散了Tisch医院和Schwartz医疗保健中心(HCC)的300多名患者, 在暴风雨中,我们的主校区的机械、电气和管道系统遭到了大规模的破坏, 要求暂时关闭我们的主校区我们现在正处于灾后恢复时期, 风暴造成的损失和评估减灾需求。 有三个基础科学建筑,Skirball研究所,Smilow研究中心和医疗中心。 科学大楼(MSB)。额外的基础科学实验室设在专门的领域,包括博士。 弗兰科的实验室位于五楼,是Milhauser实验室的一部分。地下三层 这些建筑物、斯米洛研究中心、蒂施医院和MSB受到严重破坏。动物 Smilow的动物园被认为是完全不可恢复的。将MSB动物园的动物重新安置至 卫星设施。尽管许多人做出了英勇的努力, 尽管如此,许多人仍然死亡,包括那些被基因改变用于心脏研究的品系。 疾病、癌症、自闭症和精神分裂症。Skirball研究所和Smilow研究中心 到11月12日运行;然而,MSB遭受了最广泛的破坏,维修正在进行中。 MSB的恢复将导致从今年夏天开始分阶段恢复运营。研究 Tisch医院的实验室,包括Franke博士的实验室,被搬迁到新的地点, 促进Tisch医院重新开放,用于病人护理。 由于电力中断和冷冻机故障,大量冷藏和冷冻生物标本和 试剂丢失了。尽管有这些损失,但通过运输干冰和液体, 向受影响的地区提供氮气,直到样品可以转移到场外低温储存供应商设施。
英文摘要
NYU Langone Medical Center experienced an unprecedented storm on October 29th, 2012, causing damage that deeply impacted our patient care, research, and educational facilities. NYULMC’s emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. Although we safely evacuated over 300 patients from Tisch Hospital and Schwartz Health Care Center (HCC) in the midst of the storm, our main campus incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring the temporary closure of our main campus. We are now in a post-disaster recovery period addressing the damage caused by the storm and assessing mitigation needs. There are three basic science buildings, the Skirball Institute, the Smilow Research Center, and the Medical Science Building (MSB). Additional basic science laboratories were housed in dedicated areas including Dr. Franke’s laboratory on the 5th Floor as part of the Milhauser Laboratories. The below-ground levels of three of these buildings, the Smilow Research Center, Tisch Hospital and MSB were significantly damaged. The animal vivarium of Smilow was deemed completely unrecoverable. Animals from the MSB vivarium were relocated to satellite facilities. Despite the heroic efforts of many that saved a number of rodents from the Smilow Research Center, many still perished, including lines that were genetically altered for use in the study of heart disease, cancer, autism and schizophrenia. The Skirball Institute and the Smilow Research Center were operational by November 12th; however, MSB sustained the most extensive damage, and repairs are ongoing. The restoration of MSB will result in a phased return of operations beginning this summer. Research laboratories in Tisch Hospital including Dr. Franke’s laboratory were relocated to new locations in order to facilitate the reopening of Tisch Hospital for patient care. Due to disruptions in power and freezers failing, a large number of refrigerated and frozen biospecimens and reagents were lost. Despite these losses, many samples were saved by transporting dry ice and liquid nitrogen to affected areas until the samples could be relocated to an off-site cryostorage vendor facility.
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Akt Signaling at the Crossroads of Depression and Addiction
Akt Signaling at the Crossroads of Depression and Addiction