Interaction of Mc1r with the pRb and p53 pathways in UVR-induced melanoma development

该项目将阐明引起紫外线诱发黑色素瘤（MM）的基本过程。个体之间的先天差异，独立于色素沉着，影响MM的发展。我们将研究uvr在携带基因突变（Cdk4, Arf, Mc1r）的小鼠中诱导MM发展的机制，这些基因突变支持人类MM的易感性。了解MCs对紫外线的敏感性对于针对易感人群开展健康教育活动和加强筛查至关重要。

This project will shed light onto fundamental processes causing UV-induced melanoma (MM). Innate differences between individuals, independent of pigmentation, influence MM development. We will study the mechanisms of UVR-induced MM development in mice carrying gene mutations (Cdk4, Arf, Mc1r) that underpin human MM susceptibility. Knowledge of the sensitivity of an one's MCs to UV could be critical for targeting susceptible groups for health education campaigns and more intense screening.