Brain Regulation of Reproduction: Challenging the ‘KNDy’ Hypothesis

大脑对生殖的调节：挑战“KNDy”假说

• 批准号: DP140102495
• 负责人: Prof Graeme Martin
• 金额: $ 27.28万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102495
• 关键词: Brain; Regulation; Reproduction; Challenging; KNDy

The brain switches reproduction on and off by changing the frequency of pulses of gonadotrophin releasing hormone. The processes that produce the pulses have been a puzzle for decades but, recently, brain cells that produce three peptides (kisspeptin, neurokinin B, dynorphin), known as ‘KNDy cells’, have been heralded as the ‘missing link’, or even the ‘pulse generator’. Using sheep, this project will challenge the KNDy hypothesis with pheromones and with acute increases in nutrition, two factors that rapidly increase the frequency of gonadotrophin releasing hormone pulses. The outcomes of this research are directly relevant to the optimisation of reproductive management in farm animals, wildlife and humans.

大脑通过改变促性腺激素释放激素的脉冲频率来开启和关闭生殖。几十年来，产生脉冲的过程一直是一个谜，但最近，产生三种肽（kisspeptin，神经激肽B，强啡肽）的脑细胞，称为“KNDy细胞”，被誉为“缺失的环节”，甚至是“脉冲发生器”。使用绵羊，该项目将挑战KNDy假说与信息素和急性增加营养，两个因素，迅速增加促性腺激素释放激素脉冲的频率。这项研究的结果与农场动物，野生动物和人类的生殖管理优化直接相关。