La Jolla Interdisciplinary Neuroscience Center Cores

这一跨机构NINDS P30核心补助金的总体目标是促进La Jolla机构神经学家之间新的跨学科合作，方法是允许他们接触以前被拒绝或几乎没有机会获得的科学核心，并通过促进新核心来促进最先进的技术；这些核心是在过去五年授予PI Lipton博士的NIH蓝图核心补助金(P30 NS057096)的赞助下启动的。由于整个蓝图核心资助计划已经被NIH终止，NINDS计划官员要求我们提交这份NINDS P30核心资助。为了实现我们的目标，我们选择了Blueprint Core Grant上最好的核心设施，并选择了顶尖科学家在桑福德-伯纳姆医学研究所(SBMIR)和加州大学圣地亚哥分校(UCSD)运行这些核心，以帮助拉霍亚的NINDS神经科学家。这里建议的核心包括(I)高通量(HS)图书馆筛查(在SBMRI)，(Ii)神经病理学(在UCSD)，和(Iii)电生理学(在SBMIR和Salk的Advisors)，以及(Iv)管理核心(以SBMRI为中心)。这些核心设施将向La Jolla Torrey Pines Mesa上所有四个机构的神经科学家开放，这些机构由SBMRI、加州大学洛杉矶分校、索尔克和斯克里普斯研究所组成。这些机构共享全国排名最高的神经科学研究生项目之一，并为这些核心投入了大量的机构资金。这项工作的目的是开发神经疾病的新疗法。将由所有3个科学核心和行政核心推动的具体目标如下： 1.为研究神经退行性疾病的神经学家争取核心支持。这些核心还将有助于开发神经保护疗法。在主要用户的合格NINDS项目中，这些疾病包括阿尔茨海默氏症、帕金森氏症、肌萎缩侧索硬化症和亨廷顿病。 2.为研究脑部肿瘤疾病的神经学家争取核心支持。这些疾病出现在主要使用者的合格NINDS项目中，包括多形性胶质母细胞瘤和髓母细胞瘤。 3.为研究发育障碍的神经学家争取核心支持。障碍包括神经元异常迁移，并在主要用户的NINDS资格项目中表现出来。

The overall goal of this interinstitutional NINDS P30 Core Grant is to foster new interdisciplinary collaborations among neuroscientists in La Jolla institutions by allowing access to scientific cores to which they were previously denied or had little access, and by promoting new cores to promote state-of-the-art technology; these cores were started under the prior auspices of the NIH Blueprint Core Grant (P30 NS057096) that was awarded to the PI, Dr. Lipton, for the past five years. Since the entire Blueprint Core Grant Program has been terminated by NIH, NINDS Program Officials asked us to submit this NINDS P30 Core Grant. To accomplish our goal, we have chosen among the very best core facilities on the Blueprint Core Grant, and have chosen top scientists to run these cores at the Sanford-Burnham Medical Research Institute (SBMIR) and the University of California San Diego (UCSD) in order to assist NINDS neuroscientists in La Jolla. The cores proposed here represent (i) High-Throughput (HS) Library Screening (at SBMRI), (ii) Neuropathology (at UCSD), and (iii) Electrophysiology (at SBMIR with Advisors at Salk), in addition to (iv) an Administrative Core (centered at SBMRI). These Core Facilities will be available to neuroscientists at all four institutions on the La Jolla Torrey Pines Mesa, composed of SBMRI, UCSD, Salk, and The Scripps Research Institute. These institutions share one of the top-rated neuroscience graduate programs in the country and have committed considerable institutional funds towards these cores. This work is aimed at developing new treatments for neurological disorders. The Specific Aims, which will be facilitated by all 3 Scientific Cores and the Administrative Core, are as follows: 1. To obtain Core support for Neuroscientists studying Neurodegenerative Disorders. The Cores will also help develop Neuroprotective Therapies. These disorders, represented in the Qualifying NINDS Projects of Major USERS, include Alzheimer's, Parkinson's, ALS, and Huntington's disease. 2. To obtain Core support for Neuroscientists studying Neoplastic Disorders of the brain. These disorders, represented in the Qualifying NINDS Projects of Major USERs, include glioblastoma multiforme and medulloblastoma tumors. 3. To obtain Core support for Neuroscientists studying Developmental Disorders. Disorders include abnormal neuronal migration, and are represented in NINDS Qualifying Projects of Major USERs.