DYNAMICS OF CHILDHOOD OBESITY IN PENNSYLVANIA

项目摘要：这项研究将扩展现有数据和正在进行的研究，以了解生活在400个社区的大量儿童中儿童肥胖的动态，这些社区对环境风险监管机构的要求各不相同。使用来自大型初级保健卫生系统的综合电子健康记录，我们将使用多层次和系统动态模型来研究超过55，000名儿童的肥胖动态。我们还将对来自80个社区的1150名儿童进行嵌套子研究，以研究环境的特征以及饮食和体育活动如何改变基因座特异性DNA甲基化捕获的基因表达，这将是迄今为止同类研究中最大的一项。我们还将采用系统动力学模型，由真实的数据驱动，模拟政策干预的流行病学后果，以上调或下调系统组件，从早期模型中确定为肥胖的决定因素。

Project Summary: This study will extend existing data and ongoing research to understand the dynamics of childhood obesity in a large population of children living in 400 communities that vary on environmental risk regulators. Using a comprehensive electronic health record from a large primary care health system, we will use multilevel and system dynamic models to study the dynamics of obesity in over 55,000 children. We will also conduct a nested substudy of 1150 children from a subset of 80 communities to examine how features of the environment, as well as diet and physical activity alter gene expression as captured by locus-specific DNA methylation in what will be the largest study of its kind to date. We will also employ systems-dynamic models, motivated by real data, to simulate the epidemiologic consequences of policy interventions to up- or down regulate system components identified as determinants of obesity from earlier models.