Cervical Spondylotic Myelopathy (CSM) Investigators Conference

脊髓型颈椎病 (CSM) 研究人员会议

• 批准号: 8650552
• 负责人: ZOHER GHOGAWALA
• 金额: $ 1.5万
• 依托单位: LAHEY CLINIC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-16 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650552
• 关键词: Bladder Dysfunction; Cervical; Cervical spine; Chicago; Clinical; Clinical Protocols; Clinical Trials; Consensus; Country; Coupled; Data; Disease; Dorsal; Economics; Failure; Functional disorder; Gait; Grant; Hand; Hares; Health Resources; Hospital Charges; Institute of Medicine (U.S.); Lead; Motion; Motor; Movement; Neurologic; Operative Surgical Procedures; Orthopedics; Patient Representative; Patients; Population; Population Study; Protocols documentation; Randomized Controlled Trials; Research Personnel; Spinal; Spinal Canal; Spinal Cord; Spinal Cord Diseases; Spinal cord injury; Spondylosis; Stenosis; Surgeon; Surgical Decompression; Surgical Management; Symptoms; Syndrome; United States; Vertebral column; administrative database; comparative effectiveness; compare effectiveness; cost; design; effectiveness research; improved; operation; public health relevance; spinal cord compression; symposium; treatment strategy; trial comparing

Project Summary/Abstract - Ghogawala PI Cervical Spondylotic Myelopathy (CSM) represents the most common cause of spinal cord injury in the United States and has been identified by the Institute of Medicine as being among the top 100 priorities for new comparative effectiveness research. There is a significant need for new clinical trials on surgery for CSM. Surgical decompression for CSM can improve its disabling symptoms. The optimal surgical treatment, however, remains controversial, with disagreement between three main approaches: ventral decompression and fusion, dorsal decompression and fusion, or dorsal laminoplasty. Because we do not know which operation for CSM is optimal, it is likely that many patients with this disease are not receiving the best treatment. There is a growing consensus among spinal surgeons that a randomized controlled trial (RCT) comparing these three approaches is necessary, feasible, and desirable. Our objective is to obtain a conference grant with the following specific aims: Specific Aim #1: To convene orthopaedic and neurological spine surgeon thought leaders with representative patients with CSM and other stakeholders to inform the design of an RCT to compare the effectiveness and costs of ventral versus dorsal treatment options for treating CSM. Specific Aim #2: To identify and define the optimal study population for an RCT comparing ventral and dorsal surgery for CSM. The conference will be held at the Chicago Marriott O'Hare. We expect to have 12 speakers and a total of 30 attendees. At the conclusion of the conference, the ideal population for an RCT comparing ventral and dorsal surgery for treating CSM will be identified. This information will be used to finalize a protocol for an RCT comparing different treatment strategies for CSM.

项目总结/摘要 - Ghogasala PI 脊髓型颈椎病 (CSM) 是最常见的原因 美国脊髓损伤研究所已鉴定 医学被列为新比较有效性的 100 项优先事项之一 研究。 非常需要针对 CSM 手术进行新的临床试验。外科 CSM减压可以改善其致残症状。最佳手术方式 然而，治疗仍然存在争议，三种主要的治疗方法之间存在分歧 方法：腹侧减压和融合、背侧减压和融合，或 背侧椎板成形术。因为我们不知道 CSM 的哪种操作是最佳的，所以 可能许多患有这种疾病的患者没有得到最好的治疗。有 脊柱外科医生越来越一致地认为，随机对照试验（RCT） 比较这三种方法是必要的、可行的、可取的。 我们的目标是获得会议资助，具体目标如下： 具体目标#1： 召集骨科和神经脊柱外科医生思想领袖 CSM 的代表性患者和其他利益相关者为 RCT 的设计提供信息 比较腹侧与背侧治疗方案的有效性和成本 治疗 CSM。 具体目标#2： 确定和定义比较腹侧和侧侧的随机对照试验的最佳研究人群 CSM 的背部手术。 会议将在芝加哥奥黑尔万豪酒店举行。我们期望有 12 位演讲者和总共 30 名与会者。会议结束时，理想的 比较治疗 CSM 的腹侧和背侧手术的 RCT 人群 确定。该信息将用于最终确定 RCT 比较方案 CSM 的不同治疗策略。

项目成果

Surgery vs Conservative Care for Cervical Spondylotic Myelopathy: Surgery Is Appropriate for Progressive Myelopathy.

• DOI: 10.1227/neu.0000000000000781
• 发表时间: 2015-08-01
• 期刊: Neurosurgery
• 影响因子: 4.8
• 作者: Ghogawala, Zoher;Benzel, Edward C;Heary, Robert F
• 通讯作者: Heary, Robert F

Postoperative cervical sagittal imbalance negatively affects outcomes after surgery for cervical spondylotic myelopathy.

• DOI: 10.1097/brs.0000000000000641
• 发表时间: 2014-12-01
• 期刊: Spine
• 影响因子: 3
• 作者: Roguski M;Benzel EC;Curran JN;Magge SN;Bisson EF;Krishnaney AA;Steinmetz MP;Butler WE;Heary RF;Ghogawala Z
• 通讯作者: Ghogawala Z

Cervical spondylotic myelopathy surgical trial: randomized, controlled trial design and rationale.

• DOI: 10.1227/neu.0000000000000479
• 发表时间: 2014-10
• 期刊: Neurosurgery
• 影响因子: 4.8
• 作者: Ghogawala Z;Benzel EC;Heary RF;Riew KD;Albert TJ;Butler WE;Barker FG 2nd;Heller JG;McCormick PC;Whitmore RG;Freund KM;Schwartz JS
• 通讯作者: Schwartz JS