Expansion and Enhancement of the Arkansas FERN Chemistry Laboratory

阿肯色州 FERN 化学实验室的扩建和增强

• 批准号: 8696983
• 负责人: Jeffery H Moran
• 金额: $ 37.86万
• 依托单位: ARKANSAS STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-18 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8696983
• 关键词: Expansion; Enhancement; Arkansas; FERN; Chemistry

Project Summary Large scale events like the Deepwater Horizon Oil Rig Explosion of 2010 and infant formula being purposely fortified with melamine in China cause great concern and heighten the level of awareness among Americans. Local, state, and national response mechanisms are in place to quickly respond to these situations and help mitigate unforeseen consequences while protecting public and environmental health. Unfortunately, response assets at every level can quickly become overwhelmed and may require surge or redundant capacity. The Food and Drug Administration Food Emergency Response Program (FDA FERN) is one system in place that is comprised of both federal and state laboratories that bring personnel, supplies, equipment, and expertise together to enable food and food product analyses during these situations. Many laboratories are volunteer laboratories, but 14 member laboratories have entered cooperative agreements and are now referred to as FERN CAP Laboratories. The Arkansas Department of Health-Arkansas Public Health Laboratory (ADH-PHL) became a FERN CAP Laboratory in 2009 and has been working over the past 1.5 years to provide the necessary foundation for launching the Arkansas FERN Chemistry Laboratory. This newly formed laboratory is part of rd the 3 generation of CAP laboratories. ADH-PHL provides a solid laboratory environment for maintaining the Arkansas FERN Chemistry Laboratory. Dedicated laboratory space, quality management systems, and additional surge staff, instrument, and space are available when needs arise. Laboratory systems are accredited through several internationally recognized accrediting authorities, and the entire laboratory staff brings great experience in the four key project areas of GC-MS, LC-MS, ICP-MS, and ELISA. ADH-PHL also partners with other federal response networks managed by the Centers for Disease Control and the Environmental Protection Agency, namely the Laboratory Response Network (LRN) and the Environmental Laboratory Response Network (ELRN), respectively. This internal collaboration brings together a mix of diverse skill sets along with varying degrees of expertise and experience in a way that promotes interaction and program development. These relationships are crucial for mitigating large scale crises where human and environmental health is threatened. The Arkansas FERN Chemistry Laboratory has met 100% of the goals identified in the first 2 year cooperative agreement. The laboratory is fully staffed, has obtained, installed and trained on FERN instrumentation, has worked with FERN partners to successfully validate FERN testing methods focusing on GC-MS, LC-MS, ICP- MS, and ELISA, has participated and passed all proficiency tests provided by FDA, has exercised its response capabilities, and participates in technical and programmatic meetings, which include conference calls. This laboratory continuously focuses to improve emergency response and preparedness efforts and is working with FDA to find ways to enhance and expand FERN response initiatives. FERN analysts are actively evaluating diverse food matrix assignments provided by the FDA. These matrices include powdered milk, freeze-dried tuna, spinach, mandarin oranges, pineapple juice, chocolate syrup, soy-based baby formula, snack cakes, energy drinks, drinkable yogurt, balsamic vinaigrette salad dressing, catfish, and spirits. The project plan for this cooperative agreement continues to bolster emergency response and preparedness initiatives by assessing analytical capacity, cross-training staff to provide additional surge support, proficiency testing and exercising methodologies, and participating in various training forums including meetings and conference calls reviewing programmatic and technical information. Training sessions provided by FDA and other FERN partners will also be used to help stay abreast of the newest technology being used by FERN. The project plan also includes provisions to help expand and enhance FERN response initiatives. Matrix evaluations and analyte extension studies will continue as staff cross-train with and exercise validated methods. Quantitative capabilities and technology evaluations are being explored as a way to help prepare the FERN program for future responses and requests. To help streamline reporting of data, unique data management and processing tools are being developed to help expedite final reporting. All of these measures will benefit the FERN national response program as new information is disseminated through educational courses and lectures.

项目摘要 大型事件，如2010年深水地平线石油钻井平台爆炸和故意为婴儿配方奶粉 三聚氰胺在中国中的强化引起了极大的关注，并提高了美国人的意识水平。 地方、州和国家的响应机制已经到位，以快速响应这些情况并提供帮助 在保护公众和环境健康的同时，减轻不可预见的后果。不幸的是，回应 每个级别的资产都可能很快变得不堪重负，可能需要激增或冗余容量。食物 食品和药物管理局食品紧急反应计划(FDA FERN)是一个到位的系统， 由联邦和州实验室组成，提供人员、用品、设备和专业知识 以便在这些情况下进行食品和食品产品分析。许多实验室都是自愿的 实验室，但已有14个成员实验室签订了合作协议，现在称为蕨类 卡普实验室。阿肯色州卫生部-阿肯色州公共卫生实验室(ADH-PHL) 于2009年成为蕨类CAP实验室，在过去的1.5年里一直致力于提供必要的 成立阿肯色州蕨类化学实验室基金会。这个新成立的实验室是 研发 第三代CAP实验室。 ADH-PHL为阿肯色州蕨类化学实验室的维护提供了坚实的实验室环境。 专用的实验室空间、质量管理系统以及额外的增援人员、仪器和空间 在需要时可用。实验室系统通过了几个国际公认的认证 认证机构和整个实验室工作人员在以下四个关键项目领域带来了丰富的经验 气质联用、液质联用、电感耦合等离子体质谱、酶联免疫吸附试验。ADH-PHL还与其他管理的联邦响应网络合作 由疾病控制中心和环境保护局，即实验室反应 网络(LRN)和环境实验室响应网络(ELRN)。这个内部 协作结合了不同的技能组合以及不同程度的专业知识和经验 以一种促进互动和程序开发的方式。这些关系对于缓解 人类和环境健康受到威胁的大规模危机。 阿肯色州蕨类化学实验室已100%实现了头两年合作中确定的目标 协议。该实验室人员齐全，已获得、安装和培训了蕨类仪器，拥有 与FERN合作伙伴合作，成功验证了FERN测试方法，重点是GC-MS、LC-MS、ICP-MS MS和ELISA已参加并通过FDA提供的所有熟练程度测试，已行使其回应 能力，并参加技术和方案会议，包括电话会议。这 实验室不断专注于改进应急响应和准备工作，并正在与 FDA将想方设法加强和扩大蕨类植物的应对措施。蕨类分析师正在积极评估 由FDA提供的各种食物矩阵分配。这些基质包括冷冻干燥的奶粉 金枪鱼，菠菜，橘子，菠萝汁，巧克力糖浆，豆基婴儿配方奶粉，零食蛋糕，能量 饮料、可饮用的酸奶、香醋沙拉调料、鳕鱼和烈酒。 这项合作协议的项目计划继续加强应急反应和准备工作。 通过评估分析能力、交叉培训员工来提供额外的激增支持、熟练程度等举措 测试和实施方法，并参加各种培训论坛，包括会议和 审查方案和技术信息的电话会议。由FDA提供的培训课程和 其他Fern合作伙伴也将帮助了解Fern正在使用的最新技术。这个 项目计划还包括帮助扩大和加强蕨类反应倡议的规定。矩阵求值 随着工作人员交叉培训和练习经过验证的方法，分析物扩展研究将继续进行。 目前正在探索定量能力和技术评估，以帮助准备蕨类植物 为将来的响应和请求制定计划。为了帮助简化数据报告、独特的数据管理和 正在开发处理工具，以帮助加快最后报告的速度。所有这些措施都将使 作为新信息的蕨类国家反应方案通过教育课程和讲座进行传播。