Interactions between the serotonin transporter and sympathetic nervous activation in patients with major depressive disorder - Understanding the link between the brain and the heart

点击翻译按钮获取中文摘要

There is evidence that patients with major depressive disorder (MDD) are at increased risk of developing heart disease. While the mechanisms responsible remain unknown we have previously demonstrated that cardiac sympathetic nervous activity in patients with MDD follows a bimodal distribution, with values in some patients being extraordinarily high. In this project we will determine the physiological consequences of sympathetic activation in patients with MDD.