Interactions between the serotonin transporter and sympathetic nervous activation in patients with major depressive disorder - Understanding the link between the brain and the heart

重度抑郁症患者血清素转运蛋白和交感神经激活之间的相互作用 - 了解大脑和心脏之间的联系

• 批准号: nhmrc : 1022791
• 负责人: Prof David Barton
• 金额: $ 35.15万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-serotonin-transporter-brain-heart/110219
• 关键词: Interactions; between; serotonin; transporter; sympathetic

There is evidence that patients with major depressive disorder (MDD) are at increased risk of developing heart disease. While the mechanisms responsible remain unknown we have previously demonstrated that cardiac sympathetic nervous activity in patients with MDD follows a bimodal distribution, with values in some patients being extraordinarily high. In this project we will determine the physiological consequences of sympathetic activation in patients with MDD.

有证据表明，重度抑郁症（MDD）患者患心脏病的风险增加。虽然负责的机制仍然未知，我们以前已经证明，心脏交感神经活动在MDD患者遵循双峰分布，在一些患者的值是非常高的。在这个项目中，我们将确定交感神经激活的生理后果与抑郁症患者。