Risk Factors for Atherosclerosis among Patients with Heart Failure in Kenya

项目总结(见说明)： 杰拉尔德·布鲁姆菲尔德博士是杜克大学的心脏病学研究员。候选人的长期任期 我的兴趣是成为慢性病流行病学和治疗方面的临床研究人员。 心血管疾病(CVD)在发展中国家，从而改善人们的健康 使用一级和二级预防方法的弱势群体。拟议的职业发展 计划包含多学科计划，旨在提供密集的、密切指导的、 以患者为中心的研究体验与全面结构的教学相结合 生物统计学和流行病学课程。在约翰·A·巴特利特(杜克)博士的指导下 全球卫生研究所)、鲍勃·哈林顿博士(杜克临床研究所，DCRI)、法比安博士 Esamai(肯尼亚莫伊大学医学院)和Thomas Gaziano博士(哈佛大学 Bloomfield博士将在肯尼亚采用病例对照研究设计 伴有和不伴有心力衰竭(HF)的患者。使用现代超声心动图，血清学检测和 临床评估，我们的具体目标是识别和描述心力衰竭的分类 肯尼亚第三级转介大学诊所，特别强调缺血性心脏病，以 描述心力衰竭患者中亚临床动脉粥样硬化的患病率 描述以下人群中动脉粥样硬化的可改变和不可改变危险因素的流行率 心力衰竭患者。在肯尼亚莫伊大学医学院呆了一年 在这个项目中，我们希望收集关于患者动脉粥样硬化负担的试点数据。 心力衰竭；从而为更大规模的前瞻性、地区性相关分析提供假设 未来。布卢姆菲尔德博士还将指导有抱负的肯尼亚临床研究人员，并促进 一项临床研究培训计划。候选人将拥有他可以支配的基础设施， 美国/撒哈拉以南非洲培训网络的患者人数和统计支助 和教育(Asante)财团，总部设在肯尼亚埃尔多雷特，其成员包括莫伊大学， 印第安纳大学、布朗大学和杜克大学。在第二年及以后，布卢姆菲尔德博士将 参加DCRI临床研究培训项目，亲身体验 进行国际临床试验，参加每周研究会议，在 全国性会议和手稿草稿。

PROJECT SUMMARY (See instructions): Dr. Gerald Bloomfield is a cardiology fellow-in-training at Duke University. The candidate's long-term interest is to become a clinical researcher in the epidemiology and treatment of chronic cardiovascular disease (CVD) in the developing world, thereby improving the health of the disadvantaged using primary and secondary prevention methods. The proposed career development plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience in association with a comprehensively structured didactic curriculum in biostatistics and epidemiology. Under the mentorship of Dr. John A. Bartlett (Duke Global Health Institute), Dr. Bob Harrington (Duke Clinical Research Institute, DCRI), Dr. Fabian Esamai (Moi Univei-sity School of Medicine, Kenya) and Dr. Thomas Gaziano (Harvard University School of Public Health), Dr. Bloomfield will employ a case-control research design in Kenyan patients with and without heart failure (HF). Using modern echocardiography, serologic assays and clinical assessments, our specific aims are to identify and describe the taxonomies of heart failure in a Kenyan Tertiary Referral University clinic with special emphasis on ischemic heart disease, to describe the prevalence of subclinical atherosclerosis among patients with heart failure and to describe the prevalence of modifiable and non-modifiable risk factors for atherosclerosis among patients with heart failure. By spending one year with the Moi University School of Medicine in Kenya performing this project, we hope to collect pilot data on the burden of atherosclerosis among patients with heart failure; thereby informing hypotheses for larger prospective, regionally-relevant analyses in the future. Dr Bloomfield will also mentor aspiring Kenyan clinical researchers and facilitate portions of a clinical research training program. The candidate will have at his disposal the infrastructure, patient population and statistical support of the American/Sub Saharan African Network for Training and Education (ASANTE) consortium based in Eldoret, Kenya whose members include Moi University, Indiana University, Brown University and Duke University. In years 2 and beyond, Dr. Bloomfield will take part in the DCRI clinical research training program, experience first-hand the featutes of conducting international clinical trials, attend weekly research conferences, present abstracts at national.conferences and draft manuscripts.