受体功能-猫眼课题宝

受体功能

批准号：

8577250

负责人：

DANA E SELLEY

金额：

$13.55万

依托单位：

VIRGINIA COMMONWEALTH UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8577250

关键词：

Absence of pain sensation Adverse drug effect Affective Affinity Animals Autoradiography Behavior Behavioral Binding Binding Sites Biological Assay Brain Brain region Calcium Cell Line Cell model Cell physiology Cells Cellular Morphology Cocaine Colon Comorbidity Complement Constipation Cyclic AMP Data Development Dissection Dopamine Receptor Drug abuse Endocannabinoids Exhibits Fluorescence Funding Future GTP-Binding Proteins Gastrointestinal Transit Gene Expression Generations Goals Grant HIV Histology Immunohistochemistry Instruction Investigation Lead Ligand Binding Ligands Maps Marijuana Measurement Mediating Methods Microscopic Mission Molecular Molecular Structure Neuroanatomy Neuroglia Neurons Nicotine Nucleus Accumbens Opiates Opioid Opioid Receptor Pain Pathway interactions Pharmacology Phosphoproteins Physiological Population Postdoctoral Fellow Prefrontal Cortex Primary Cell Cultures Publications Reader Receptor Activation Receptor Signaling Reporter Genes Research Research Personnel Resources Rewards Role Second Messenger Systems Services Signal Transduction Signaling Protein Site Structure-Activity Relationship Students System Techniques Time Tissues Training Transgenic Organisms Ventral Tegmental Area Virginia arrestin B base brain cell cannabinoid receptor cell type cellular imaging chemokine receptor dopamine transporter drug mechanism drug of abuse gastrointestinal system ileum innovation insight interest neurochemistry new therapeutic target novel opiate tolerance radioligand receptor receptor binding receptor density receptor function receptor internalization receptor-mediated signaling relating to nervous system screening second messenger small molecule stimulant abuse trafficking

中文摘要

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英文摘要

PROJECT SUMMARY (See instructions): The primary mission of this core will be to provide services, facilities and training to facilitate the study of receptors or related small molecule targets, such as transporters, with a goal of enhancing research in drug abuse and related co-morbidities. Services will include measurement of receptor binding, receptor localization, receptor signaling (with a primary focus on GPCRs, although not limited to GPCRs), receptor trafficking and receptor-protein interaction. The core will also perform moderate-throughput ligand screening to determine small molecular structure-activity relationships at particular target sites. The core will also provide relevant tissue preparative functions, such as tissue sectioning and primary cell culture development, for core studies. Finally the core will provide relevant training for PIs, students or post-doctoral fellows.

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