受体功能-猫眼课题宝

受体功能

批准号：

8577250

负责人：

DANA E SELLEY

金额：

$13.55万

依托单位：

VIRGINIA COMMONWEALTH UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/8577250

关键词：

Absence of pain sensation Adverse drug effect Affective Affinity Animals Autoradiography Behavior Behavioral Binding Binding Sites Biological Assay Brain Brain region Calcium Cell Line Cell model Cell physiology Cells Cellular Morphology Cocaine Colon Comorbidity Complement Constipation Cyclic AMP Data Development Dissection Dopamine Receptor Drug abuse Endocannabinoids Exhibits Fluorescence Funding Future GTP-Binding Proteins Gastrointestinal Transit Gene Expression Generations Goals Grant HIV Histology Immunohistochemistry Instruction Investigation Lead Ligand Binding Ligands Maps Marijuana Measurement Mediating Methods Microscopic Mission Molecular Molecular Structure Neuroanatomy Neuroglia Neurons Nicotine Nucleus Accumbens Opiates Opioid Opioid Receptor Pain Pathway interactions Pharmacology Phosphoproteins Physiological Population Postdoctoral Fellow Prefrontal Cortex Primary Cell Cultures Publications Reader Receptor Activation Receptor Signaling Reporter Genes Research Research Personnel Resources Rewards Role Second Messenger Systems Services Signal Transduction Signaling Protein Site Structure-Activity Relationship Students System Techniques Time Tissues Training Transgenic Organisms Ventral Tegmental Area Virginia arrestin B base brain cell cannabinoid receptor cell type cellular imaging chemokine receptor dopamine transporter drug mechanism drug of abuse gastrointestinal system ileum innovation insight interest neurochemistry new therapeutic target novel opiate tolerance radioligand receptor receptor binding receptor density receptor function receptor internalization receptor-mediated signaling relating to nervous system screening second messenger small molecule stimulant abuse trafficking

中文摘要

翻译

项目总结（见说明）：该中心的主要使命将是提供服务、设施和培训，以促进受体或相关小分子目标（如转运蛋白）的研究，目的是加强对药物滥用和相关并发症的研究。服务将包括受体结合、受体定位、受体信号传导（主要关注GPCR，但不限于GPCR）、受体运输和受体-蛋白质相互作用的测量。该核心还将进行中等通量的配体筛选，以确定特定靶位点处的小分子结构-活性关系。核心还将为核心研究提供相关的组织制备功能，如组织切片和原代细胞培养开发。最后，核心将为专业人员、学生或博士后研究员提供相关培训。

英文摘要

PROJECT SUMMARY (See instructions): The primary mission of this core will be to provide services, facilities and training to facilitate the study of receptors or related small molecule targets, such as transporters, with a goal of enhancing research in drug abuse and related co-morbidities. Services will include measurement of receptor binding, receptor localization, receptor signaling (with a primary focus on GPCRs, although not limited to GPCRs), receptor trafficking and receptor-protein interaction. The core will also perform moderate-throughput ligand screening to determine small molecular structure-activity relationships at particular target sites. The core will also provide relevant tissue preparative functions, such as tissue sectioning and primary cell culture development, for core studies. Finally the core will provide relevant training for PIs, students or post-doctoral fellows.

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