Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches

通过补充方法解决神经炎症和持续性疼痛

基本信息

批准号：
9703529
负责人：
Joseph P Mathew
金额：
$ 169.97万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-20 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9703529
关键词：
Acute Acute Pain Address Animal Model Anticonvulsants Antidepressive Agents Anxiety Basic Science Behavior Biomedical Engineering Catechol O-Methyltransferase Clinical Trials Complementary Health Complementary therapies Complex Data Collection Disease Docosahexaenoic Acids Electroacupuncture Enzymes Eucalyptol Event Female Fish Oils Fracture Future Genetic Goals Inflammation Inflammation Mediators Inflammatory Integrative Medicine Lead Leg Life Maintenance Measures Mediating Mediator of activation protein Medicine Mental Depression Modeling Molecular Mus Natural Products Nervous system structure Neuroglia Neuroimmunomodulation Opioid Organism Pain Pain management Persistent pain Pharmacological Treatment Phenotype Play Postoperative Pain Pre-Clinical Model Predisposition Process Research Research Personnel Resolution Sampling Stress Synaptic plasticity Testing Therapeutic Therapeutic Effect Time Translations Trigeminal System Trigeminal nerve structure Tumor-infiltrating immune cells Validation Ventilatory Depression addiction behavior measurement behavioral construct chemotherapy chronic pain chronic pain management clinical pain clinically relevant common treatment comorbidity environmental stressor experimental study immune activation indexing insight nerve injury neuroinflammation neuronal excitability neuroprotectin D1 neuroregulation opioid epidemic pain relief pain symptom painful neuropathy programs response sample collection sex tissue injury

项目摘要

The goal of this program project is to establish a NCCIH Center of Excellence is to investigate neuroinflammatory mechanisms underlying multiple complementary and integrative health (CIH) approaches, including electroacupuncture and natural product docosahexaenoic acids. The overarching hypothesis for the entire P01 is that different CIH approaches may modify distinct inflammatory and neuroinflammatory profiles to achieve their therapeutic potentials in pain management. This hypothesis will be tested in 4 projects using four animal models relevant to different types of clinical pain conditions, in combination with sex and stress. In response to rising opioid crisis in the US, this PPG will conduct cutting-edge basic science research and pave the road for future clinical trial at the center for rapid translation of the identified complementary approaches that can effectively modulate neuroinflammation.

该计划项目的目的是建立NCCIH卓越中心是调查神经炎症多种互补和综合健康（CIH）方法的机制，包括电针和天然产物二十六烯酸。整个P01的总体假设是，不同的CIH方法可能会改变不同的炎症和神经炎性谱以实现他们在疼痛管理中的治疗潜力。该假设将在4个项目中使用四种动物进行检验与不同类型的临床疼痛状况相关的模型，结合性别和压力。响应美国PPG的阿片类药物危机正在上升，将进行尖端的基础科学研究，并为未来的临床试验，用于快速翻译中心的互补方法有效调节神经炎症。