Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches

通过补充方法解决神经炎症和持续性疼痛

• 批准号: 9703529
• 负责人: Joseph P Mathew
• 金额: $ 169.97万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-20 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9703529
• 关键词: Acute; Acute Pain; Address; Animal Model; Anticonvulsants; Antidepressive Agents; Anxiety; Basic Science; Behavior; Biomedical Engineering; Catechol O-Methyltransferase; Clinical Trials; Complementary Health; Complementary therapies; Complex; Data Collection; Disease; Docosahexaenoic Acids; Electroacupuncture; Enzymes; Eucalyptol; Event; Female; Fish Oils; Fracture; Future; Genetic; Goals; Inflammation; Inflammation Mediators; Inflammatory; Integrative Medicine; Lead; Leg; Life; Maintenance; Measures; Mediating; Mediator of activation protein; Medicine; Mental Depression; Modeling; Molecular; Mus; Natural Products; Nervous system structure; Neuroglia; Neuroimmunomodulation; Opioid; Organism; Pain; Pain management; Persistent pain; Pharmacological Treatment; Phenotype; Play; Postoperative Pain; Pre-Clinical Model; Predisposition; Process; Research; Research Personnel; Resolution; Sampling; Stress; Synaptic plasticity; Testing; Therapeutic; Therapeutic Effect; Time; Translations; Trigeminal System; Trigeminal nerve structure; Tumor-infiltrating immune cells; Validation; Ventilatory Depression; addiction; behavior measurement; behavioral construct; chemotherapy; chronic pain; chronic pain management; clinical pain; clinically relevant; common treatment; comorbidity; environmental stressor; experimental study; immune activation; indexing; insight; nerve injury; neuroinflammation; neuronal excitability; neuroprotectin D1; neuroregulation; opioid epidemic; pain relief; pain symptom; painful neuropathy; programs; response; sample collection; sex; tissue injury

The goal of this program project is to establish a NCCIH Center of Excellence is to investigate neuroinflammatory mechanisms underlying multiple complementary and integrative health (CIH) approaches, including electroacupuncture and natural product docosahexaenoic acids. The overarching hypothesis for the entire P01 is that different CIH approaches may modify distinct inflammatory and neuroinflammatory profiles to achieve their therapeutic potentials in pain management. This hypothesis will be tested in 4 projects using four animal models relevant to different types of clinical pain conditions, in combination with sex and stress. In response to rising opioid crisis in the US, this PPG will conduct cutting-edge basic science research and pave the road for future clinical trial at the center for rapid translation of the identified complementary approaches that can effectively modulate neuroinflammation.

该计划项目的目标是建立一个 NCCIH 卓越中心来研究神经炎症 多种补充和综合健康（CIH）方法背后的机制，包括 电针和天然产物二十二碳六烯酸。整个P01的总体假设 不同的 CIH 方法可能会改变不同的炎症和神经炎症特征，以实现 他们在疼痛管理方面的治疗潜力。该假设将在 4 个项目中使用四种动物进行测试 与不同类型的临床疼痛状况相关的模型，并结合性别和压力。作为回应 美国阿片类药物危机愈演愈烈，PPG将开展前沿基础科学研究，为阿片类药物危机铺平道路 未来的临床试验中心将快速转化已确定的补充方法，这些方法可以 有效调节神经炎症。