Global Infectious Diseases and HPV Research Training in Kenya

摘要 人乳头瘤病毒（HPV）是世界上最常见的性传播感染， 低收入和中低收入国家（LMIC）。几乎所有的宫颈癌都是由于 持续的HPV感染，87%的宫颈癌死亡发生在LMIC。检测、预防和 因此，治疗人乳头瘤病毒感染是该国和该区域的一个主要卫生优先事项。阿加汗大学东校区 非洲（AKU）是一个首屈一指的医疗和护理学术机构，独特的地理位置，以解决全球传染病 疾病和HPV。这是一所不断发展的大学，在肯尼亚、乌干达和坦桑尼亚设有校区， 为东非的医生设立了第一个临床传染病（ID）奖学金。但要实现 AKU的目标是成为顶级研究机构，需要进一步的研究能力建设和支持培训 在AKU拥有大量具有深入科学专业知识的健康研究人员。这项建议的目的是 1）增加对HPV感染的预防、检测和治疗及其对人类健康的影响的研究。 癌症; 2）加强AKU进行传染病研究的能力; 3）扩大 在东非AKU校园的临床研究的知识和技能。拟议研究 培训项目将由Marleen Temmerman博士和Michael Chung博士领导，他们将是多个项目的负责人。 董事们。他们将与华盛顿大学（UW）及其悠久的历史合作， 在肯尼亚成功实施研究培训计划。华盛顿大学已经培训了数百名肯尼亚人， 30多年的健康研究。UW也是由教师领导的世界知名的HPV研究小组的所在地 来自华盛顿大学和弗雷德哈钦森癌症研究中心的专家。特莫曼医生和钟医生 为肯尼亚人建立一个联合研究培训方案，分三个阶段，时间长短不一。长期 轨道将允许AKU ID研究员通过参加以下课程获得UW公共卫生硕士学位（MPH） 西雅图，并在肯尼亚进行实地考察;中期轨道将邀请AKU医疗和护理 教师研究人员在华盛顿大学3个月的课程，然后在肯尼亚的一个指导项目; 短期跟踪将为AKU教师，员工和学生在整个东非提供机会， 通过在肯尼亚内罗毕举办面对面研讨会，学习赠款和手稿写作以及领导技能 和来自华盛顿大学的在线课程。共有3名AKU ID研究员将在UW获得MPH学位，10名AKU教师 成员将在华盛顿大学接受非学位课程，数百名学员将参加研讨会， 在线课程毕业后，ID研究员将在AKU提供学术医疗职位，并加入教师队伍 以及在AKU接受过中期和短期课程培训的工作人员，以建立可持续的研究 容量到该计划结束时，AKU教师将能够进行高质量的HPV研究，发表在 国际公认的期刊，开展培训下一代HPV科学家的课程， 独立获得校外赠款，以支持他们的工作。

ABSTRACT Human papillomavirus (HPV) is the most common sexually transmitted infection in the world with 85% of infections occurring in low and lower middle income countries (LMIC). Nearly all cervical cancer is due to persistent HPV infection with 87% of all cervical cancer deaths occurring in LMIC. Detecting, preventing, and treating HPV infection is thus a major health priority for the country and the region. Aga Khan University East Africa (AKU) is a premier medical and nursing academic institution uniquely situated to address global infectious diseases and HPV. It is a growing university with campuses in Kenya, Uganda, and Tanzania, and it has initiated the first clinical infectious diseases (ID) fellowship for medical doctors in East Africa. However, in order to achieve its goal to become a top research institution, AKU needs further research capacity building and support to train a critical mass of health researchers at AKU with in-depth scientific expertise. The objectives of this proposal are to: 1) increase research into the prevention, detection, and treatment of HPV infection and its impact on cancer; 2) strengthen the capacity of AKU to conduct research in infectious diseases; and 3) expand knowledge and skills in clinical research across AKU campuses in East Africa. The proposed research training program will be led by Drs. Marleen Temmerman and Michael Chung who will be Multiple Program Directors. Together, they will partner AKU with the University of Washington (UW) and its extensive history of successfully implementing research training programs in Kenya. The UW has trained hundreds of Kenyans in health research for over 30 years. UW is also home to a world-renowned HPV Research Group led by faculty experts from the UW and the Fred Hutchinson Cancer Research Center. Drs. Temmerman and Chung will establish a joint research training program for Kenyans with three tracks of varying duration. The long-term track will allow AKU ID fellows to earn a UW Master’s in Public Health (MPH) degree by taking classes in Seattle and conducting fieldwork in Kenya; the medium-term track will invite AKU medical and nursing faculty researchers for 3 months of classes at UW followed by a mentored project in Kenya; and the short-term track will give an opportunity for AKU faculty, staff, and students throughout East Africa to learn grant and manuscript writing and leadership skills through in-person workshops in Nairobi, Kenya and online courses from the UW. A total of 3 AKU ID fellows will earn MPH degrees at the UW, 10 AKU faculty members will undergo non-degree coursework at the UW, and hundreds of trainees will take the workshops and online courses. After graduating, the ID fellows will be offered academic medical positions at AKU and join faculty and staff who have been trained in the medium- and short-term courses at AKU to build sustainable research capacity. By the end of the program, AKU faculty will be able to conduct quality HPV research, publish in internationally-recognized journals, conduct courses to train the next generation of HPV scientists, and independently obtain extramural grants to support their work.