Pulmonary and Critical Care Post-Doctoral Research Training Program

描述(由申请者提供)：我们寻求为这一成功的医生-科学家培训项目重新提供资金，该项目于2007年1月首次授予。我们计划的目标是开发两条综合但不同的途径，提供“临床试验、流行病学、比较有效性和结果研究”以及“细胞和动物炎症模型的转化方法”方面的综合科学培训。在这次更新中，我们建议包括儿科的教师导师和博士后实习生，他们将专注于儿科和新生儿肺部疾病。我们计划的基本组成部分是开发一个强大的导师平台，以支持内科科学家成功的学术生涯；该平台采用强化和多样化的方法，为已经完成或将完成成人肺部医学、重症护理医学或新生儿学临床培训并对学术生涯有强烈承诺的候选人提供正式的科学培训。我们的目标是在科学知识体系中培训高度精选的个人，这些知识与炎症和先天免疫在广泛的肺和肺血管疾病中的主要和次要作用有关。我们认为，这一科学平台广泛适用于具有显著炎症特征的最广泛的各种肺部疾病，包括哮喘和慢性阻塞性肺病、间质性肺病、职业性和环境性肺病、急性呼吸窘迫综合征、婴幼儿慢性肺病和新生儿肺动脉高压等非常普遍的疾病。我们假设，在儿童和成人肺部疾病的背景下，专注于临床和基础研究的综合计划将激励新一代成功的内科科学家。所有学员将制定个性化的研究计划，学习撰写拨款申请，并在学术就业安置方面接受职业咨询和帮助。受训者及其导师的进展将由一个研究咨询委员会、内部执行委员会、外部咨询委员会和首席调查员密切监测。我们的计划旨在伦理和科学负责的环境中强调新颖的分子方法，并坚定地致力于吸引来自代表性不足的少数群体的个人。

DESCRIPTION (provided by applicant): We seek to renew funding for this successful physician-scientist training program that was first awarded in January 2007. The goal of our program is to develop two integrated but separate pathways that provide integrated scientific training in "clinical trials, epidemiology, comparative effectiveness, and outcomes research" and in "translational approaches in cellular and animal models of inflammation." In this renewal, we propose to include faculty mentors from the Department of Pediatrics and post- doctoral trainees who will focus on pediatric and neonatal lung diseases. The fundamental component of our program has been to develop a strong mentorship platform to support successful academic careers for physician-scientists; one that employs an intensive and diverse approach to formal scientific training for candidates who have completed or will complete clinical training in adult pulmonary medicine, critical care medicine, or neonatology and who have a strong commitment to an academic career. We aim to train highly select individuals in a scientific body of knowledge that is related to the primary and secondary role of inflammation and innate immunity in a wide spectrum of lung and pulmonary vascular diseases. We believe that this scientific platform pertains broadly to the widest variety of lung diseases that share a prominent inflammatory feature and include the very prevalent diseases of asthma and COPD, interstitial lung disease, occupational and environmental lung disease, acute respiratory distress syndrome, chronic lung disease of infancy and pulmonary hypertension in the newborn. We hypothesize that an integrated program that is focused on both clinical and basic research in the context of both pediatric and adult lung diseases will inspire a new generation of successful physician-scientists. All trainees will develop an individualized research program, learn to write grant proposals, and receive career counseling and assistance in academic job placement. The progress of the trainees and their mentors will be closely monitored by a research advisory committee, internal executive committee, external advisory board, and the principal investigator. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from under-represented minorities.