Pulmonary and Critical Care Post-Doctoral Research Training Program

描述（由申请人提供）：我们寻求为这个于2007年1月首次授予的成功的医生-科学家培训计划重新提供资金。我们计划的目标是开发两个集成但独立的途径，提供“临床试验，流行病学，比较有效性和结果研究”和“炎症细胞和动物模型的转化方法”的综合科学培训。“在这次更新中，我们建议包括来自儿科系的教师导师和博士后学员，他们将专注于儿科和新生儿肺部疾病。我们计划的基本组成部分是开发一个强大的导师平台，以支持医生科学家成功的学术生涯;一个采用密集和多样化的方法，为已经完成或将完成成人肺医学，重症监护医学或呼吸病学临床培训的候选人进行正式的科学培训，并对学术生涯做出坚定的承诺。我们的目标是在一个科学的知识体系中培养高度选择的个体，该知识体系与炎症和先天免疫在广泛的肺和肺血管疾病中的主要和次要作用有关。我们认为，这一科学平台广泛适用于具有突出炎症特征的最广泛的肺部疾病，包括哮喘和COPD、间质性肺病、职业和环境性肺病、急性呼吸窘迫综合征、婴儿慢性肺病和新生儿肺动脉高压等非常普遍的疾病。我们假设，在儿科和成人肺部疾病的背景下，专注于临床和基础研究的综合计划将激励新一代成功的医生科学家。所有学员将制定一个个性化的研究计划，学习写赠款建议，并接受职业咨询和学术就业安置援助。研究咨询委员会、内部执行委员会、外部咨询委员会和首席研究员将密切监测学员及其导师的进展。我们的计划旨在强调在道德和科学上负责任的环境中的新型分子方法，并致力于吸引来自代表性不足的少数民族的个人。

DESCRIPTION (provided by applicant): We seek to renew funding for this successful physician-scientist training program that was first awarded in January 2007. The goal of our program is to develop two integrated but separate pathways that provide integrated scientific training in "clinical trials, epidemiology, comparative effectiveness, and outcomes research" and in "translational approaches in cellular and animal models of inflammation." In this renewal, we propose to include faculty mentors from the Department of Pediatrics and post- doctoral trainees who will focus on pediatric and neonatal lung diseases. The fundamental component of our program has been to develop a strong mentorship platform to support successful academic careers for physician-scientists; one that employs an intensive and diverse approach to formal scientific training for candidates who have completed or will complete clinical training in adult pulmonary medicine, critical care medicine, or neonatology and who have a strong commitment to an academic career. We aim to train highly select individuals in a scientific body of knowledge that is related to the primary and secondary role of inflammation and innate immunity in a wide spectrum of lung and pulmonary vascular diseases. We believe that this scientific platform pertains broadly to the widest variety of lung diseases that share a prominent inflammatory feature and include the very prevalent diseases of asthma and COPD, interstitial lung disease, occupational and environmental lung disease, acute respiratory distress syndrome, chronic lung disease of infancy and pulmonary hypertension in the newborn. We hypothesize that an integrated program that is focused on both clinical and basic research in the context of both pediatric and adult lung diseases will inspire a new generation of successful physician-scientists. All trainees will develop an individualized research program, learn to write grant proposals, and receive career counseling and assistance in academic job placement. The progress of the trainees and their mentors will be closely monitored by a research advisory committee, internal executive committee, external advisory board, and the principal investigator. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from under-represented minorities.