Integrated approach to protein biomarker identification in Huntington Disease

亨廷顿病蛋白质生物标志物鉴定的综合方法

• 批准号: 8740576
• 负责人: DANIEL CHELSKY
• 金额: $ 54.83万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8740576
• 关键词: Biological Assay; Biological Markers; Blood; Brain; Cerebrospinal Fluid; Clinical; Collection; Communities; Data; Data Set; Databases; Diagnosis; Disease; Disease Progression; Economics; Future; Gene Mutation; Huntington Disease; Marker Discovery; Measures; Methods; Mining; Molecular; Motor; Neuraxis; Pattern; Peptides; Peripheral; Physiological; Plasma; Probability; Proteins; Proteolysis; Proteomics; Sampling; Source; Statistical Data Interpretation; Time; Tissue Sample; Validation; analytical tool; assay development; base; brain tissue; clinical decision-making; cohort; cost effective; deamidation; drug development; literature survey; mutation carrier; oxidation; public health relevance; tool

DESCRIPTION (provided by applicant): This project proposes the mining of plasma and cerebrospinal fluid (CSF) biomarkers of disease progression in Huntington Disease (HD) using the latest analytical tools to accelerate future treatment studies.

描述(由申请人提供)：该项目建议使用最新的分析工具挖掘亨廷顿病(HD)疾病进展的血浆和脑脊液(CSF)生物标记物，以加快未来的治疗研究。