Amygdala Mediated Enhancement of Object Recognition Memory in the Hippocampus

杏仁核介导海马体物体识别记忆的增强

• 批准号: 8723882
• 负责人: David I. Bass
• 金额: $ 4.55万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723882
• 关键词: Address; Amygdaloid structure; Arousal; Basal Ganglia; Basic Science; Behavior; Clinical; Clinical Treatment; Cognition; Cognitive; Complex; Disease; Electric Stimulation; Emotional; Emotions; Event; Functional disorder; Goals; Hippocampus (Brain); Individual; Knowledge; Lesion; Literature; Location; Mediating; Memory; Memory Disorders; Mental disorders; Neurons; Outcome; Output; Pattern; Physicians; Physiological; Physiology; Post-Traumatic Stress Disorders; Process; Rattus; Research; Research Project Grants; Role; Scientist; Services; Testing; Therapeutic; Training; base; career; design; insight; long term memory; novel; object recognition; relating to nervous system; response

DESCRIPTION (provided by applicant): An extensive body of literature indicates that emotion modulates memory. Moderate levels of emotional arousal enhance memory, but extreme levels of emotional arousal impair memory and might be related to clinical disorders such as post-traumatic stress disorder. Numerous studies indicate that the amygdala is a crucial hub for coordinating both the cognitive and physiological responses to emotion, including the responses that modulate memory. Projections from the basal nucleus of the amygdala to the hippocampus are in part responsible for enhancing hippocampus dependent memory, such as novel object recognition. The project will address how the input from the amygdala modulates neuronal activity in the hippocampus in the service of enhancing memory. Specifically, electrical stimulation of the basal nucleus of the amygdala will be combined with neural recordings in the hippocampus in order to investigate how the amygdala projections to the hippocampus can enhance memory representations in the hippocampus. The expected outcomes will be relevant to potential therapeutic strategies for memory enhancement as well as to disorders in which abnormal amygdalo-hippocampal interactions are thought to be prevalent, including post-traumatic stress disorder. The proposed research project will also serve as a framework for the applicant's training plan, which was specifically designed to integrate basic research on amygdalo-hippocampal interactions with the applicant's career goal of becoming a physician-scientist whose focus will be neurosurgical treatments of psychiatric disorders.

描述(由申请者提供)：大量文献表明情绪调节记忆。适度的情绪唤醒可以增强记忆，但极度的情绪唤醒会削弱记忆，并可能与创伤后应激障碍等临床障碍有关。大量研究表明，杏仁核是协调对情绪的认知和生理反应的关键中枢，包括调节记忆的反应。从杏仁核到海马体的投射在一定程度上负责增强海马体依赖记忆，例如新物体识别。该项目将阐述杏仁核的输入如何调节海马体中的神经元活动，以增强记忆。具体地说，电刺激杏仁核基底核将与海马区的神经记录相结合，以研究杏仁核向海马区的投射如何增强海马区的记忆表征。预期结果将与增强记忆的潜在治疗策略以及杏仁核-海马体异常相互作用被认为普遍存在的障碍有关，包括创伤后应激障碍。拟议的研究项目还将作为申请者培训计划的框架，该计划专门设计用于将杏仁核-海马体相互作用的基础研究与申请者的职业目标相结合，即成为一名内科科学家，重点是精神疾病的神经外科治疗。