Predoctoral and Postdoctoral Training in Cancer Cell Biology

描述(由申请者提供)：本提案请求支持基础癌细胞生物学的博士后和博士后培训计划。该计划的目标是为在学术机构或行业从事基础或临床相关癌症研究的受训人员做准备。培训人员来自细胞和分子医学(DCCM)、内科、儿科、药理和外科、摩尔大学圣迭戈分校癌症中心、路德维希癌症研究所(LICR)和霍华德·休斯医学院(HHMI)。教师包括活跃在基础和临床前转化性癌症研究中的个人。该项目是医学院唯一的癌症生物学博士后和博士后培训项目，并被整合到生物医学(BMS)研究生项目中，这是一个基础广泛的项目，涉及细胞和分子生物学、遗传学/基因组学、免疫学、药理学和生理学。培训人员强烈认为，要治愈癌细胞中发生的细胞过程紊乱，需要详细了解正常和异常细胞行为的分子、细胞和遗传学方面，以及它们在癌症研究中的应用。 教师：29名教师中的每一位在其所在领域都是国际公认的，有着出色的培训记录，并拥有对了解癌症细胞生物学至关重要的研究兴趣--包括细胞周期控制、癌基因和抗癌基因、调节激酶、信号、生长控制、G蛋白和生长因子、细胞运动控制、癌细胞的糖生物学、细胞和分子基因组学，以及实验性抗癌疗法的发展。 实习生：博士前实习生将从BMS研究生项目的学生中挑选，根据他们对从事基础癌细胞生物学研究的兴趣以及他们的学术和研究表现。博士后实习生将根据他们的学术成就和对癌症研究事业的兴趣，从申请培训学院实验室职位的人中挑选出来。我们正在招聘16年的6个博士后和2个博士后职位，逐步增加到20年达到6个博士后实习生。受训人员需要完成癌症专业实习生计划的要求，包括每月一次的研究研讨会和年度务虚会，以及癌症研究方面的课程，关于癌症细胞/分子生物学的负责任的研究，教程，小组会议，出席DCMM/Ludwig联合研讨会系列，以及由Moore UCSD癌症中心赞助的关于癌症的临床方面和肿瘤细胞对各种治疗的反应的系列研讨会。

DESCRIPTION (provided by applicant): This proposal requests support for a predoctoral and postdoctoral training program in basic Cancer Cell Biology. The program goal is to prepare trainees for careers in basic or clinically-related Cancer Research in academic institutions or industry. The training faculty are drawn from the Departments of Cellular and Molecular Medicine (DCCM), Medicine, Pediatrics, Pharmacology and Surgery, the Moore's UCSD Cancer Center, the Ludwig Institute for Cancer Research (LICR), and the Howard Hughes Medical Institute (HHMI). The faculty includes individuals active in both basic and preclinical translational cancer research. This program is the only predoctoral and postdoctoral cancer biology training program based in the School of Medicine and is integrated into the Biomedical Sciences (BMS) Graduate Program which is a broadly based program in cell and molecular biology, genetics/genomics, immunology, pharmacology and physiology. The training faculty strongly believes that to cure the derangements of cell processes that occur in cancer cells requires detailed understanding of the molecular, cellular and genetic aspects of normal and abnormal cell behavior and their application to cancer research. Faculty: Each of the 29 faculty is internationally recognized in his/her field, has an outstanding training record, and has research interests that are fundamental to understanding cancer cell biology-- including cell cycle control, oncogenes and anti-cancer genes, regulatory kinases, signaling, growth control, G proteins and growth factors, control of cell movement, glycobiology of cancer cells, cellular and molecular genomics, and the development of experimental anticancer therapeutics. Trainees: Predoctoral trainees will be selected from students in the BMS graduate program based on their interest in undertaking research in basic cancer cell biology and on the strength of their academic and research performance. Postdoctoral trainees will be selected from those applying for positions in the laboratories of the training faculty based on their academic achievements and interest in a career in cancer research. We are requesting 6 predoctoral and 2 postdoctoral positions in year 16 increasing gradually to reach 6 postdoctoral trainees in year 20. Trainees are required to complete the specialized Cancer Trainee Program requirements, including a monthly research workshop and annual retreat and courses in Cancer Research, the Responsible Conduct of Research, tutorials, small group conferences on the cellular/molecular biology of cancer, attendance at the joint DCMM/Ludwig seminar series as well as a seminar series on the clinical aspects of cancer and the response of tumor cells to various treatments sponsored by the Moores UCSD Cancer Center.