Mentoring New Investigators in Criminal Justice HIV Prevention and Treatment

指导刑事司法艾滋病毒预防和治疗方面的新​​调查人员

• 批准号: 8731476
• 负责人: DAVID A WOHL
• 金额: $ 18.28万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8731476
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adopted; Affect; Anti-Retroviral Agents; Area; Award; Back; Caring; Characteristics; Clinical; Clinical Investigator; Clinical Research; Clinical Trials Unit; Communicable Diseases; Communities; Continuity of Patient Care; Counseling; Criminal Justice; Data Analyses; Data Collection; Detection; Development; Diagnosis; Directly Observed Therapy; Discrimination; Disease; Doctor of Philosophy; Educational process of instructing; Environment; Epidemic; Evidence based intervention; Faculty; Failure; Fellowship; Fostering; Funding; Future; Gap Junctions; Goals; HIV; HIV Infections; Human immunodeficiency virus test; Imprisonment; Individual; Infectious Diseases Research; Intake; Intervention; Interview; Investigation; Leadership; Left; Maintenance; Mental disorders; Mentors; Mentorship; Methodology; Methods; Modeling; Modification; Motivation; North Carolina; Participant; Perception; Personal Satisfaction; Persons; Population; Positioning Attribute; Poverty; Prevention; Prisoner; Prisons; Public Health; Public Health Schools; Publications; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Self Medication; Services; Site; Students; Substance abuse problem; System; Techniques; Testing; Time; Training; Training Programs; Training and Education; Translating; United States National Institutes of Health; Universities; Virus; Vulnerable Populations; Woman; Work; arm; base; career; cohort; correctional system; design; electronic data; experience; falls; improved; interest; medical schools; men; next generation; patient oriented research; professor; programs; public health relevance; screening; skills; social stigma; substance abuse treatment; transmission process; working group

DESCRIPTION (provided by applicant): David Alain Wohl, MD, an Associate Professor in the Division of Infectious Diseases at the University of North Carolina (UNC), submits this application for a K24 Mid-Career award. The purpose of the K24 is to enable recipients to: a) Devote more time to augment their capabilities in Patient-Oriented Research (POR); and b) Provide mentoring to new clinical investigators in the conduct of POR. Dr. Wohl is a nationally recognized thought-leader in HIV clinical research - particularly that exploring the nexus between incarceration and HIV. In this application he proposes to develop skills that will serve his future work in this significant area of research including qualitative data collection and analysis methodology, higher-level analytical techniques, and strategies for effective leadership. He will expand an established record of mentorship to develop greater capacity and research opportunities in order to foster the research careers of early investigators. Candidate: Dr. Wohl has been a highly productive HIV clinical researcher and has established UNC as a major center for HIV-related corrections research. Since 2003, he has been continuously NIH-funded to conduct research aiming to optimize HIV detection and care for people involved in the criminal justice system, a population with prevalent substance abuse and mental health disorders, and has directly translated the findings of three R01-supported investigations into modification of practice in the NC prison system. Based on his investigations, the NC prison system has adopted antiretroviral self-medication instead of universal directly observed therapy, shifted to voluntary opt-out HIV testing on intake, and developed new transitional care models for HIV-infected releasees. Further, Dr. Wohl has a strong record of teaching and mentorship of new investigators, supporting procurement of awards and first-authored publications by mentees, as well as independence of these talented investigators. Mentoring Plan/Environment: This application will leverage the extensive training resources at UNC including the Center for AIDS Research (CFAR), the School of Public Health-based K30 training program, the School of Medicine MD/PhD program, and the UNC Infectious Diseases research fellowship - each of which Dr. Wohl is deeply involved with. As a founder and Co-Director of the UNC CFAR Prison Working Group, Site Leader of the UNC AIDS Clinical Trials Unit, and Director of the NC AIDS Training and Education Center (ATEC), Dr. Wohl is well-positioned to access and mentor students, fellows and junior faculty within and beyond UNC. As requests for mentoring have increased, Dr. Wohl proposes to receive formal and informal guidance to develop further as a mentor. Further, to better serve those he supervises and enhance his own productively, he seeks this award to strengthen and enhance his data collection and analytical skills including qualitative and quantitative data collection and analysis. Research Plan: The established research infrastructure Dr. Wohl and his collaborators have built, including the establishment of cohorts of HIV-infected and -uninfected prison releasees, and his collaborative relationships with the prison system, public health entities, and other research groups, serve as a platform to provide ample opportunities for mentee research. There remain a number of highly significant questions to be answered across the cascade of HIV care, including: What are the best methods to conduct HIV screening and linkage to care in prison in a manner respects individual autonomy? To what extent are HIV-infected prisoners engaged in care while incarcerated? Can intransigent individual (e.g., substance abuse, mental health disorders, low motivation) and structural (e.g., poverty, discrimination, stigma) obstacles to linkage to HIV care and services after release be surmounted, and if so, how? The K24 support will permit Dr. Wohl the time to pursue work that are natural extensions of his research, and provide rich opportunities for mentee research while protecting time to support his devotion to mentorship.

描述（由申请人提供）：大卫阿兰沃尔，医学博士，在传染病科副教授在北卡罗来纳州（北卡罗来纳州）的大学，提交了K24中期职业奖的申请。K24的目的是使接受者能够：a）投入更多的时间来增强他们在以患者为导向的研究（POR）中的能力;以及B）为新的临床研究者提供指导。沃尔博士是全国公认的艾滋病毒临床研究的思想领袖，特别是探索监禁与艾滋病毒之间的联系。在此申请中，他提议培养将服务于他未来在这一重要研究领域工作的技能，包括定性数据收集和分析方法、更高层次的分析技术以及有效领导策略。他将扩大导师的既定记录，以发展更大的能力和研究机会，以促进早期研究人员的研究事业。候选人：Wohl博士是一位高产的艾滋病毒临床研究人员，并已建立了一个艾滋病毒相关的矫正研究的主要中心。自2003年以来，他一直不断NIH资助进行研究，旨在优化艾滋病毒检测和护理的人参与刑事司法系统，人口与流行的药物滥用和精神健康障碍，并直接翻译了三个R 01支持的调查结果，在NC监狱系统的实践修改。根据他的调查，北卡罗来纳州监狱系统采用了抗逆转录病毒自我治疗，而不是普遍的直接观察治疗，转向自愿选择不接受艾滋病毒检测，并为感染艾滋病毒的释放者开发了新的过渡性护理模式。Wohl拥有良好的教学和指导新研究人员的记录，支持学员获得奖项和第一作者的出版物，以及这些有才华的研究人员的独立性。指导计划/环境：此应用程序将利用广泛的培训资源，包括艾滋病研究中心（CFAR），公共卫生为基础的K30培训计划，医学博士/博士课程的学校，和传染病研究奖学金的学校-其中每一个博士。作为艾滋病临床试验单位的现场负责人，以及NC艾滋病培训和教育中心（ATEC）的主任，Wohl博士处于有利地位，可以访问和指导学生，研究员和初级教师。随着对指导的要求越来越多，Wohl博士建议接受正式和非正式的指导，以进一步发展为导师。此外，为了更好地服务于他所监督的人，并提高自己的生产力，他寻求这个奖项，以加强和提高他的数据收集和分析技能，包括定性和定量数据收集和分析。研究计划：Wohl博士及其合作者建立的研究基础设施，包括建立艾滋病毒感染者和未感染者的队列，以及他与监狱系统，公共卫生实体和其他研究小组的合作关系，作为一个平台，为学员研究提供了充足的机会。在艾滋病毒护理的各个环节中，仍有一些非常重要的问题有待回答，包括：在尊重个人自主权的情况下，进行艾滋病毒筛查和与监狱护理挂钩的最佳方法是什么？感染艾滋病毒的囚犯在监禁期间在多大程度上得到照料？不妥协的个人（例如，物质滥用、精神健康障碍、动机低下）和结构性（例如，（a）如何克服释放后与艾滋病毒护理和服务挂钩的障碍，如果是，如何克服？Wohl有时间从事他的研究的自然延伸工作，并为学员研究提供丰富的机会，同时保护时间来支持他对导师的奉献。