Molecular Design of Advanced Biomaterials

先进生物材料的分子设计

• 批准号: 8710695
• 负责人: Tatyana Polenova
• 金额: $ 117万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710695
• 关键词: Address; Award; Basic Science; Biochemistry; Biocompatible Materials; Biological; Biology; Biomaterials Research; Centers of Research Excellence; Collaborations; Communities; Computer Simulation; Core Facility; Delaware; Development; Engineering; Faculty; Funding; Lead; Liver Regeneration; Mass Spectrum Analysis; Mechanics; Mentors; Microscopy; Molecular; Nuclear Magnetic Resonance; Organic Chemistry; Pharmaceutical Preparations; Phase; Property; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Surface; Testing; Tissues; Translational Research; United States National Institutes of Health; Universities; biophysical chemistry; career; design; instrumentation; lectures; meetings; novel; programs; public health relevance; success; symposium; vocal cord

DESCRIPTION (provided by applicant): We propose to build on the success of COBRE phase I and phase II awards to establish four research cores that will provide the infrastructure to take our Center to the next level. In addition, COBRE III will provide a mechanism for pilot research projects to continue to develop vibrant teams of investigators in biomaterials research. Significant biomedical therapies are likely to emerge from novel biomaterials that are designed at the molecular level to offer customized control over mechanical and biological properties. The realization of such biomaterials requires synergy between diverse research communities of organic chemistry, molecular design, biochemistry, biology, biophysical chemistry, and materials engineering. Collaborations between an outstanding group of junior, mid-career and senior investigators spanning multiple units across campus were established during phase I and phase II COBRE awards and will be extended in COBRE III. We propose four specific aims for COBRE III: i) to develop state-of-the-art self-sustained research instrumentation cores (Nuclear Magnetic Resonance; Mass Spectrometry and Surface Characterization; Microscopy and Mechanical Testing; and Computational Modeling) that will be integrated into campus-wide infrastructure; ii) to establish a pilot research subproject program that will enable the PIs to initiate new research directions, to bring new junior investigators to the COBRE program, and to promote new collaborations; iii) to establish COBRE-supported symposia and meetings (an annual research and coordination retreat, and co-sponsored lectures in biomaterials); and iv) to establish a COBRE faculty mentoring program. These aims will further the development of a cadre of NIH ROI funded investigators whose cutting-edge biomaterial research programs will provide continuing support for the core facilities that are a crucial for regenerative medicine research at the University of Delaware.

描述（由申请人提供）：我们建议建立在COBRE第一阶段和第二阶段奖励的成功基础上，建立四个研究核心，为采取 我们的中心到一个新的水平。此外，COBRE III将为试点研究项目提供一个机制，以继续发展生物材料研究方面充满活力的研究人员团队。重要的生物医学疗法可能会出现在分子水平上设计的新型生物材料中，以提供对机械和生物特性的定制控制。这种生物材料的实现需要有机化学、分子设计、生物化学、生物学、生物物理化学和材料工程等不同研究领域之间的协同作用。在第一阶段和第二阶段COBRE奖励期间，一组优秀的初级、中级和高级研究人员跨越校园的多个单位建立了合作，并将在COBRE III中扩展。我们提出了COBRE III的四个具体目标：i）开发最先进的自我维持研究仪器核心（核磁共振）， 共振;质谱和表面表征;显微镜和机械测试;和计算建模），将被整合到校园范围内的基础设施; ii）建立一个试点研究子项目计划，使PI能够启动新的研究方向，使新的初级研究人员的COBRE计划，并促进新的合作; iii）建立COBRE支持的专题讨论会和会议（年度研究和协调务虚会，以及共同主办的生物材料讲座）; iv）建立COBRE教师指导计划。这些目标将进一步发展NIH ROI资助的研究人员骨干，其尖端生物材料研究计划将为核心设施提供持续支持，这些设施对再生医学研究至关重要， 特拉华州大学。