Molecular Design of Advanced Biomaterials

先进生物材料的分子设计

• 批准号: 8710695
• 负责人: Tatyana Polenova
• 金额: $ 117万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710695
• 关键词: Address; Award; Basic Science; Biochemistry; Biocompatible Materials; Biological; Biology; Biomaterials Research; Centers of Research Excellence; Collaborations; Communities; Computer Simulation; Core Facility; Delaware; Development; Engineering; Faculty; Funding; Lead; Liver Regeneration; Mass Spectrum Analysis; Mechanics; Mentors; Microscopy; Molecular; Nuclear Magnetic Resonance; Organic Chemistry; Pharmaceutical Preparations; Phase; Property; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Surface; Testing; Tissues; Translational Research; United States National Institutes of Health; Universities; biophysical chemistry; career; design; instrumentation; lectures; meetings; novel; programs; public health relevance; success; symposium; vocal cord

DESCRIPTION (provided by applicant): We propose to build on the success of COBRE phase I and phase II awards to establish four research cores that will provide the infrastructure to take our Center to the next level. In addition, COBRE III will provide a mechanism for pilot research projects to continue to develop vibrant teams of investigators in biomaterials research. Significant biomedical therapies are likely to emerge from novel biomaterials that are designed at the molecular level to offer customized control over mechanical and biological properties. The realization of such biomaterials requires synergy between diverse research communities of organic chemistry, molecular design, biochemistry, biology, biophysical chemistry, and materials engineering. Collaborations between an outstanding group of junior, mid-career and senior investigators spanning multiple units across campus were established during phase I and phase II COBRE awards and will be extended in COBRE III. We propose four specific aims for COBRE III: i) to develop state-of-the-art self-sustained research instrumentation cores (Nuclear Magnetic Resonance; Mass Spectrometry and Surface Characterization; Microscopy and Mechanical Testing; and Computational Modeling) that will be integrated into campus-wide infrastructure; ii) to establish a pilot research subproject program that will enable the PIs to initiate new research directions, to bring new junior investigators to the COBRE program, and to promote new collaborations; iii) to establish COBRE-supported symposia and meetings (an annual research and coordination retreat, and co-sponsored lectures in biomaterials); and iv) to establish a COBRE faculty mentoring program. These aims will further the development of a cadre of NIH ROI funded investigators whose cutting-edge biomaterial research programs will provide continuing support for the core facilities that are a crucial for regenerative medicine research at the University of Delaware.

描述（由申请人提供）：我们建议建立I阶段第一阶段和第二阶段奖项的成功，以建立四个研究核心，这些核心将提供基础架构 我们的中心到一个新的高度。此外，Cobre III将为试点研究项目提供一种机制，以继续开发生物材料研究中的研究人员团队。在分子水平设计的新型生物材料中可能会出现重要的生物医学疗法，以提供对机械和生物学特性的自定义控制。这种生物材料的实现需要有机化学，分子设计，生物化学，生物学，生物物理化学和材料工程的各种研究社区之间的协同作用。在第一阶段和第二阶段的柯布雷奖中建立了跨越校园多个单位的杰出初级，职业生涯和高级调查员之间的合作，并将在Cobre III中扩展。我们提出了四个针对毛cre III的特定目标：i）开发最先进的自我维持的研究仪器（核磁磁力） 谐振;质谱和表面表征；显微镜和机械测试；和计算建模）将集成到校园范围内的基础架构中； ii）建立一项试点研究副本计划，该计划将使PIS能够启动新的研究指示，将新的初级调查人员带入COBRE计划，并促进新的合作； iii）建立脚踏实地的研讨会和会议（年度研究与协调撤退，以及在生物材料中的共同赞助的讲座）；和iv）建立一个毛茸茸的教师指导计划。这些目标将进一步发展一批NIH ROI资助的调查人员，其尖端的生物材料研究计划将为核心设施提供持续的支持，这对于对再生医学研究至关重要的核心设施。 特拉华大学。