Functional Approach to Communication Sound Processing in Mouse Auditory Cortex

小鼠听觉皮层通信声音处理的功能方法

基本信息

批准号：
8706843
负责人：
Robert C Liu
金额：
$ 34.57万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8706843
关键词：
Accounting Acoustics Address Adult Affect Animal Model Animals Area Auditory Auditory Perceptual Disorders Auditory area Auditory system Behavioral Biological Assay Caring Categories Code Communication Communication impairment Complex Cues Detection Discrimination Disease Distress Electrophysiology (science)Estrogens Exposure to Female Functional disorder Future Goals Hearing Home environment Life Experience Mediating Molecular Mothers Mus Neuronal Plasticity Neurons Neurosciences Play Process Research Retrieval Role Sensory Shapes Shipping Ships Social Behavior Social Environment Social Interaction Stream Stroke System Temporal Lobe Testing Text Transgenic Organisms Ultrasonography Variant Visual Work awake base court experience extracellular hearing impairment male mouse model neurochemistry operation pup relating to nervous system response social sound vocalization

项目摘要

PROJECT SUMMARY Auditory research into the neural basis of communication sound processing has generally been conducted without accounting for the social contexts in which communication naturally occurs. Hence, how the auditory system is able detect, discriminate and categorize communication calls despite natural speaker variability is poorly understood, as are the mechanisms by which social interactions affect this processing. Our long-term goal is to uncover the circuit, cellular and molecular mechanisms underlying the auditory system's encoding of socially-acquired vocalizations, so that causes underlying deficits in natural communication processing can be inferred. We pursue this in a mouse model of ultrasound communication wherein two categories of calls (those emitted by mouse pups and by adult males) carry different meanings and can have different levels of behav- ioral relevance to a female. The objective here is to uncover how the representation of these call categories is transformed by hierarchical processing from a primary to a higher-order auditory cortical field, and how differ- ent natural social experiences with the calls produce coding changes. Our central hypothesis is that the trans- formation refines call coding to facilitate communication tasks, and that social experience and neurochemical systems modify this neural transformation as behavioral relevance is acquired. The rationale for this research is that once we know the manner by which neural plasticity in auditory cortex shapes the coding of behaviorally relevant calls, we will be able to exploit the transgenic advantages of the mouse model to dissect the detailed mechanisms enabling these changes. Using extracellular electrophysiology in awake mice, we will test our hy- pothesis with three specific aims. First, we will determine how the neural transformation normally functions to refine the encoding of behaviorally relevant calls by recording from animals that recognize the significance of pup calls (mothers). Second, we will determine how social experience with pups modifies this neural transfor- mation by recording from virgin females that help care for pups (co-carers). Third, we will determine how a key social neurochemical implicated in pup call recognition, estrogen, works with pup care experience to modify the neural transformation by recording from hormonally manipulated co-carers. This proposal's significance lies in its unique ability to bridge the scientific gap between sensory and social/behavioral neuroscience in an animal model in which we can pursue future studies of a high level auditory function (communication) from a system down to a molecular level.

项目摘要通常已经进行了通信声音处理的神经基础的听觉研究不考虑自然发生沟通的社会环境。因此，听觉如何尽管天然扬声器的可变性是知名度不佳，社会互动影响这种处理的机制也是如此。我们的长期目标是揭示听觉系统编码的电路，细胞和分子机制社会可获得的发声，因此自然交流处理的根本缺陷可以是推断。我们在超声通信的鼠标模型中进行此操作，其中有两类呼叫（这些小鼠幼崽和成年男性发出的含义不同，行为水平不同与女性的意义相关。这里的目的是揭示这些呼叫类别的表示通过分层处理从主要的听觉皮质场进行转换，以及如何不同带有呼叫的自然社会体验会产生编码变化。我们的核心假设是转移编队完善呼叫编码以促进沟通任务，以及社交经验和神经化学系统将这种神经转化修改为获得行为相关性。这项研究的理由是一旦我们知道听觉皮层中神经可塑性的方式塑造行为上的编码相关电话，我们将能够利用鼠标模型的转基因优势来剖析详细的实现这些变化的机制。在清醒小鼠中使用细胞外电生理学，我们将测试我们的Hy- 具有三个特定目的的势力。首先，我们将确定神经转化通常如何发挥作用通过从动物中记录来认识到重要性的动物，完善行为相关呼叫的编码小狗打电话（母亲）。其次，我们将确定与幼崽的社交经验如何修饰这种神经的经历。通过记录有助于照顾幼崽（联合车手）的处女女性的记录。第三，我们将确定如何关键与幼犬识别，雌激素有关的社会神经化学与幼犬护理经验一起工作以修改通过从荷尔蒙操纵的联合加入者记录的神经转化。该提议的意义在于它独特的能力，可以弥合动物中感觉与社会/行为神经科学之间的科学差距我们可以从系统中追求对高级听觉功能（通信）的未来研究的模型降至分子水平。