Understanding substance use and incident HIV/STI among young black MSM

了解年轻黑人男男性接触者的药物使用和艾滋病毒/性传播感染事件

基本信息

  • 批准号:
    8770948
  • 负责人:
  • 金额:
    $ 68.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-15 至 2019-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Understanding substance use and incident HIV/STI among young black MSM Project Summary/Abstract Racial/ethnic disparities in HIV have been a hallmark of the US HIV epidemic for decades, with black/African Americans experiencing higher rates of HIV infection than white Americans. These disparities are also observed in men who have sex with men (MSM), among whom the highest incidence rates are in young black/African American MSM (YBAAMSM). Despite a rich literature demonstrating the prevalent levels of drug and alcohol use among MSM and the potential relationships between these substances and high-risk sexual behaviors, individual risk behaviors do not explain why black MSM and YBAAMSM are more likely to become infected with HIV, compared to other MSM. Studies of self-reported use have collectively demonstrated no greater substance use among black MSM than among white MSM. However, a key finding of our previous R01, which examined factors associated with prevalent and incident HIV infection among a prospective cohort of black and white MSM in Atlanta, was that black MSM had substantially lower validity of self-reported drug use, compared to white MSM. Biomarker-classified drug use was also more predictive of HIV seroconversions than self-reported sexual behavior measures, suggesting that, in this population, substance use may be a marker of high-risk partners and environments. Furthermore, the racial disparity in prevalent HIV infection was most associated with differences in network and community factors rather than individual factors. Despite emerging data on sexual partners and structures among YBAAMSM, little is known about the overlap of sexual and substance-use networks, though this might amplify HIV/STI transmission risk. Therefore, we propose to conduct a new prospective cohort study of 300 HIV-negative YBAAMSM in Atlanta, GA, to understand prospective patterns of biomarker-supported substance use in YBAAMSM, as well as its antecedents, contexts, and consequences. This new project will build on the strong institutional infrastructure, community partnerships, theoretical frameworks, analytical approaches, and multidisciplinary research that contributed to the success of our previous cohort study. Results will provide a more detailed understanding of the multilevel associations between substance use and HIV risk, and will yield new opportunities for combination interventions that address the syndemics of HIV/STI and drug use among YBAAMSM.
描述(由申请者提供):了解年轻黑人MSM中的药物使用和艾滋病毒/性传播感染事件摘要/摘要数十年来,艾滋病毒中的种族/民族差异一直是美国艾滋病毒流行的一个标志,黑人/非裔美国人的艾滋病毒感染率高于美国白人。在男男性行为者(MSM)中也观察到了这些差异,其中年轻的黑人/非裔美国人MSM(YBAAMSM)的发病率最高。尽管有丰富的文献证明了MSM中毒品和酒精的普遍使用水平,以及这些物质与高危性行为之间的潜在关系,但个人危险行为并不能解释为什么黑人MSM和YBAAMSM比其他MSM更有可能感染艾滋病毒。对自我报告的使用情况的研究共同证明,黑人MSM中的物质使用量并不比白人MSM中的大。然而,我们之前的R01研究了与亚特兰大黑人和白人MSM预期队列中流行和事件HIV感染相关的因素,其中的一个关键发现是,与白人MSM相比,黑人MSM自我报告药物使用的有效性要低得多。生物标记物分类的药物使用也比自我报告的性行为指标更能预测艾滋病毒血清转换,这表明在这一人群中,物质使用可能是高危伴侣和环境的标记物。此外,艾滋病毒感染流行的种族差异主要与网络和社区因素的差异有关,而不是个人因素。尽管YBAAMSM中性伴侣和结构的数据不断涌现,但人们对性网络和药物使用网络的重叠知之甚少,尽管这可能会放大艾滋病毒/性传播疾病的传播风险。因此,我们建议对佐治亚州亚特兰大的300名HIV阴性的YBAAMSM进行一项新的前瞻性队列研究,以了解YBAAMSM中生物标记物支持物质使用的预期模式,以及其前因、背景和后果。这个新项目将建立在强大的机构基础设施、社区伙伴关系、理论框架、分析方法和多学科研究的基础上,这些都有助于我们之前的队列研究取得成功。这些结果将使人们更详细地了解药物使用和艾滋病毒风险之间的多层次联系,并将为综合干预措施提供新的机会,以解决艾滋病毒/性传播感染和青年艾滋病/性传播感染和药物使用之间的综合问题。

项目成果

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Eli Samuel Rosenberg其他文献

Eli Samuel Rosenberg的其他文献

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{{ truncateString('Eli Samuel Rosenberg', 18)}}的其他基金

Understanding substance use and incident HIV/STI among young black MSM
了解年轻黑人男男性接触者的药物使用和艾滋病毒/性传播感染事件
  • 批准号:
    9057496
  • 财政年份:
    2014
  • 资助金额:
    $ 68.19万
  • 项目类别:

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