Identification and validation of B-cell epitopes on ricin toxin

蓖麻毒素 B 细胞表位的鉴定和验证

• 批准号: 8936761
• 负责人: JOLIE COLOMB
• 金额: $ 157.2万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8936761
• 关键词: Antibodies; Antibody-mediated protection; Award; B-Lymphocyte Epitopes; Bioterrorism; Computer software; Contracts; Data; Databases; Emerging Communicable Diseases; Epitopes; Evaluation; Goals; Human; Humoral Immunities; Immune; In Vitro; Pathogenesis; Resources; Ricin; Sampling; Toxin; Validation; in vivo; neutralizing antibody; novel; programs

The contracts awarded under this program support multi-disciplinary teams to identify novel B cell epitopes and elucidate mechanisms of antibody-mediated protection or pathogenesis that are important in humoral immunity in humans to emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. Each milestone-driven contract includes 1) epitope identification; 2) epitope validation that must include in vitro evaluation using human samples; 3) submission of epitope data, computer software, and structural data to the Immune Epitope Database and Analysis Resource; and 4) studies to help understand the mechanisms of protection or pathogenesis elicited by antibodies associated with the newly identified epitopes.

根据该计划授予的合同支持多学科团队识别新的B细胞表位，并阐明抗体介导的保护或致病机制，这些机制在人类对新出现和重新出现的传染病以及生物恐怖主义及其毒素的潜在病原体的体液免疫中具有重要作用。每个里程碑驱动的合同包括1)表位识别；2)表位验证，必须包括使用人类样本进行体外评估；3)向免疫表位数据库和分析资源提交表位数据、计算机软件和结构数据；以及4)帮助了解与新识别的表位相关的抗体所引发的保护机制或致病机制的研究。