Assessment of Effectiveness of IMPT vs. IMRT through Phase II Randomized Clinical Trials

通过 II 期随机临床试验评估 IMPT 与 IMRT 的有效性

• 批准号: 8716843
• 负责人: BRUCE D. MINSKY
• 金额: $ 39.11万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8716843
• 关键词: Acute; Adverse effects; Aftercare; Bathing; Biological; Biological Assay; Biological Markers; Biological Preservation; Blood; Brain; Brain Neoplasms; Cancer Patient; Caring; Charge; Clinical; Clinical Trials; Clinical effectiveness; Cognitive; Common Terminology Criteria for Adverse Events; DNA; Data; Development; Disorder by Site; Dose; Effectiveness; Esophagitis; Failure; Goals; Half-Life; Head and Neck Cancer; Human Herpesvirus 4; Image; Kinetics; Lead; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Measures; Mission; Mucositis; Nasopharynx Carcinoma; Non-Small-Cell Lung Carcinoma; Normal tissue morphology; Oropharyngeal Neoplasms; Outcome; Patients; Pattern; Penetration; Phase; Photons; Plasma; Pneumonia; Primary carcinoma of the liver cells; Progression-Free Survivals; Property; Protocols documentation; Protons; Public Health; Quality of life; Radiation; Radiation therapy; Randomized; Randomized Clinical Trials; Recovery; Relative (related person); Research; Sampling; Specific qualifier value; Testing; Time; Toxic effect; Tumor Volume; Uncertainty; United States; Xerostomia; base; chemotherapy; cognitive function; improved; in vivo; novel; particle; programs; proton therapy; treatment response; tumor

The primary goal of this project is to evaluate, through phase II randomized clinical trials for brain, head and neck, lung and liver cancers, the effectiveness of intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon radiotherapy (commonly referred to as IMRT). The overall long-term goal and the expected outcome ofthe proposed research is the development of proton therapy strategies which maximally exploit the physical as well as biological properties of protons to improve clinical outcomes. The common theme ofthe proposed trials is acute and late toxicity reduction, quality of life (QOL) improvement and, potentially, improvement in local control and survival. This project supports the mission ofthe NCI to improve the treatment and continuing care of cancer patients.

该项目的主要目标是通过II期随机临床试验评估脑、头和 颈部，肺癌和肝癌，强度调制质子治疗（IMPT）相对于 调强光子放射治疗（通常称为IMRT）。总体长期目标和 所提出的研究的预期结果是质子治疗策略的发展， 最大限度地利用质子的物理和生物特性来改善临床结果。的 拟议试验的共同主题是减少急性和晚期毒性，改善生活质量（QOL） 以及潜在的局部控制和生存的改善。该项目支持NCI的使命， 改善癌症患者的治疗和持续护理。