High Speed ICG Ranibizumab AMD (08-EI-0103)

用雷尼单抗治疗AMD患者脉络膜新生血管的ICG分析表明，尽管减少了渗出，但对实际脉络膜新生血管的影响很小。根据吲哚菁绿血管造影分级，初步一年的结果显示脉络膜新生血管膜的平均大小只有5%的变化。

ICG analysis of choroidal neovascularization in AMD treated with ranibizumab suggests that there is minimal effect on the actual choroidal neovascularization despite reduction in exudation. The preliminary one year results showed only a 5% change in the mean size of the choroidal neovascular membrane as graded with indocyanine green angiography. Minimal intensity projection OCT is a novel algorithm that identifies and displays the minimum optical intensity found between the internal limiting membrane and retinal pigment epithelium. The software was initially developed to provide an en face fundus image where fluid presented as dark regions. Surprisingly, bright areas were also noted and these seem to correspond to the outer retinal area overlying the choroidal neovascularization. The one year results showed a mean 6% increase in the area of outer retinal change noted with minIpOCT. These data suggest that anti-VEGF treatment in the form of ranibizumab has mininal effect on the culprit choroidal neovascularization itself. This provides useful data to assess other potential neovascular age related macular degeneration treatments. The study was closed in fiscal year 2014, based on a common termination date for all participants.