Immune dysfunction and pulmonary hypertension in primate model of HIV infection

HIV感染灵长类动物模型中的免疫功能障碍和肺动脉高压

• 批准号: 9404231
• 负责人: Karen A Norris
• 金额: $ 23.85万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-03 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9404231
• 关键词: Immune; dysfunction; pulmonary; hypertension; primate

 DESCRIPTION (provided by applicant): Within the context of chronic HIV infection, pulmonary arterial hypertension (PAH) is a life-threatening complication characterized by pulmonary vascular remodeling, elevated pulmonary arterial pressure and right heart failure. Lack of understanding of the pathogenesis of HIV-PAH, along with deficiencies of available animal models, greatly impede identification and testing of new therapies. In this proposal, the overall objectives will focus on 1) determination of the role of chronic immune activation and inflammation on the development of PAH in a non-human primate model of HIV-PAH and 2) the evaluation of the effectiveness of anti-retroviral therapy, conventional PAH therapy and anti-inflammatory therapy in the primate model. These studies will not only address the mechanisms associated with the development of HIV-PAH, but they will provide critical information regarding the timing and targets that may be amenable to therapies aimed at both prevention and resolution of vascular damage, hemodynamic alterations and right heart dysfunction.