Sleep Disordered Breathing and Incident Cognitive Decline and Dementia: ARIC

睡眠呼吸障碍与认知衰退和痴呆症事件:ARIC

基本信息

  • 批准号:
    8738710
  • 负责人:
  • 金额:
    $ 11.17万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-09-20 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Dementia and mild cognitive impairment are common among U.S elderly, yet despite their immense and growing burden relatively little is known about characteristics which lead to cognitive decline. Recent evidence, both epidemiological and pathophysiological, has suggested a possible relation between abnormal sleep characteristics and cognitive impairment due to both vascular etiologies and Alzheimer's disease. However, understanding of this relation is in its infancy. We propose to explore the relation of abnormal sleep characteristics to risk of cognitive impairment over 15 years of follow-up utilizing data fro the Atherosclerosis Risk in Communities (ARIC) cohort and the Sleep Heart Health Study. ARIC is a population-based prospective epidemiologic cohort, which has had several follow-up visits, including a visit in 1996-1998 (Visit 4, ages 54-73) and an ongoing visit (ARIC Visit 5/Neurocognitive Study (ARIC NCS, 2011-2013, ages 69-88)). The Sleep Heart Health Study, which included a subset of ARIC participants, took place in (1995-1998), at approximately the same time as ARIC Visit 4. A total of 1,892 individuals participated in both ARIC Visit 4 and had in-home overnight polysomnography as part of the Sleep Heart Health Study. We hypothesize that that abnormal sleep characteristics (inclusive of measures of hypoxia and disordered breathing, sleep fragmentation, and sleep duration) in middle age are associated with risk of cognitive impairment later in life. Several cognitive phenotypes will be explored, utilizing comprehensive neurocognitive data presently being collected through ARIC-NCS. These include 1) clinical dementia and mild cognitive impairment, 2) cognitive decline as assessed by change in 3 cognitive tests administered at ARIC Visit 4 (1996-1998) and repeated in ARIC NCS (2011-2013), and 3) brain MRI markers of cerebral vascular disease (i.e. white matter hyper-intensity volume, number of lacunar infarcts) and Alzheimer's disease (i.e. hippocampal and gray matter volume). Results from the proposed study will have a profound impact on the understanding of relations between sleep in middle-age and cognition in later life. Abnormal sleep characteristics and cognitive impairment are both highly prevalent among older adults, and abnormal sleep characteristics are amenable to modification through existing interventions. Therefore, elucidating whether abnormal sleep characteristics play a role in the etiology of cognitive impairment is of vital public health importance.
描述(由申请人提供):痴呆症和轻度认知障碍在美国老年人中很常见,但尽管他们的负担巨大且不断增加,但对导致认知能力下降的特征知之甚少。流行病学和病理生理学的最新证据表明,由于血管病因学和阿尔茨海默病,异常睡眠特征和认知障碍之间可能存在联系。然而,对这种关系的理解还处于起步阶段。 我们建议利用社区动脉粥样硬化风险(ARIC)队列和睡眠心脏健康研究的数据,通过15年的随访,探讨异常睡眠特征与认知障碍风险的关系。ARIC是一个基于人群的前瞻性流行病学队列,已进行了多次随访,包括1996-1998年的一次访视(访视4,年龄54-73岁)和一次持续访视(ARIC访视5/神经认知研究(ARIC NCS,2011-2013,年龄69-88岁))。睡眠心脏健康研究,其中包括一个子集的ARIC参与者,发生在(1995-1998),大约在同一时间的ARIC访问4。共有1,892人参加了ARIC第4次访视,并在家中进行了夜间多导睡眠描记,作为睡眠心脏健康研究的一部分。 我们假设中年人的异常睡眠特征(包括缺氧和呼吸紊乱,睡眠碎片和睡眠持续时间的测量)与以后生活中认知障碍的风险相关。几个认知表型将进行探讨,利用目前正在通过ARIC-NCS收集的全面的神经认知数据。这些包括1)临床痴呆和轻度认知障碍,2)通过ARIC访视4时进行的3项认知测试的变化评估的认知下降(1996-1998年),并在ARIC NCS中重复(2011-2013),和3)脑血管疾病的脑MRI标志物(即,白色物质高强度体积、腔隙性梗死的数量)和阿尔茨海默病(即,海马体和灰质体积)。 这项研究的结果将对理解中年睡眠与晚年认知之间的关系产生深远的影响。异常睡眠特征和认知障碍在老年人中非常普遍,并且异常睡眠特征可以通过现有干预措施进行改变。因此,阐明异常的睡眠特征是否在认知障碍的病因学中发挥作用具有重要的公共卫生意义。

项目成果

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PAMELA L. Lutsey其他文献

PAMELA L. Lutsey的其他文献

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{{ truncateString('PAMELA L. Lutsey', 18)}}的其他基金

Mentoring and Research in Patient-Oriented Cardiovascular Pharmacoepidemiology
以患者为中心的心血管药物流行病学的指导和研究
  • 批准号:
    10281638
  • 财政年份:
    2021
  • 资助金额:
    $ 11.17万
  • 项目类别:
Mentoring and Research in Patient-Oriented Cardiovascular Pharmacoepidemiology
以患者为中心的心血管药物流行病学的指导和研究
  • 批准号:
    10450836
  • 财政年份:
    2021
  • 资助金额:
    $ 11.17万
  • 项目类别:
Mentoring and Research in Patient-Oriented Cardiovascular Pharmacoepidemiology
以患者为中心的心血管药物流行病学的指导和研究
  • 批准号:
    10657650
  • 财政年份:
    2021
  • 资助金额:
    $ 11.17万
  • 项目类别:
Contemporary Venous Thromboembolism Treatment
现代静脉血栓栓塞治疗
  • 批准号:
    9235562
  • 财政年份:
    2017
  • 资助金额:
    $ 11.17万
  • 项目类别:
Sleep Disordered Breathing and Incident Cognitive Decline and Dementia: ARIC
睡眠呼吸障碍与认知衰退和痴呆症事件:ARIC
  • 批准号:
    8621673
  • 财政年份:
    2013
  • 资助金额:
    $ 11.17万
  • 项目类别:
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
双种族 ARIC 队列中的血清维生素 D 和心血管疾病风险
  • 批准号:
    8434290
  • 财政年份:
    2011
  • 资助金额:
    $ 11.17万
  • 项目类别:
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
双种族 ARIC 队列中的血清维生素 D 和心血管疾病风险
  • 批准号:
    8107202
  • 财政年份:
    2011
  • 资助金额:
    $ 11.17万
  • 项目类别:
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
双种族 ARIC 队列中的血清维生素 D 和心血管疾病风险
  • 批准号:
    8279218
  • 财政年份:
    2011
  • 资助金额:
    $ 11.17万
  • 项目类别:
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
双种族 ARIC 队列中的血清维生素 D 和心血管疾病风险
  • 批准号:
    8471760
  • 财政年份:
    2011
  • 资助金额:
    $ 11.17万
  • 项目类别:
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
双种族 ARIC 队列中的血清维生素 D 和心血管疾病风险
  • 批准号:
    8695445
  • 财政年份:
    2011
  • 资助金额:
    $ 11.17万
  • 项目类别:
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