Investigating NMDA receptor-mediated pathological mechanisms underlying epilepsy and associated neurological disorders

点击翻译按钮获取中文摘要

Genetic epilepsies are debilitating neurological disorders that are frequently associated with mutations in genes encoding voltage-sensitive and neurotransmitter-gated ion channels. Several forms of severe epilepsy have recently been shown to arise from hereditary mutations in excitatory NMDA receptors. The goal of this project is to understand how these mutations alter the structure and function of NMDA receptors, and to identify potential new drug treatment strategies.