Investigating NMDA receptor-mediated pathological mechanisms underlying epilepsy and associated neurological disorders

研究 NMDA 受体介导的癫痫及相关神经系统疾病的病理机制

• 批准号: nhmrc : GNT1156673
• 金额: $ 59.28万
• 依托单位: University of the Sunshine Coast
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-nmda-receptor-neurological-disorders/1378951
• 关键词: Investigating; NMDA; receptor; mediated; pathological

Genetic epilepsies are debilitating neurological disorders that are frequently associated with mutations in genes encoding voltage-sensitive and neurotransmitter-gated ion channels. Several forms of severe epilepsy have recently been shown to arise from hereditary mutations in excitatory NMDA receptors. The goal of this project is to understand how these mutations alter the structure and function of NMDA receptors, and to identify potential new drug treatment strategies.

遗传性癫痫是一种使人衰弱的神经系统疾病，通常与编码电压敏感和神经递质门控离子通道的基因突变有关。几种形式的严重癫痫最近被证明是由兴奋性NMDA受体的遗传突变引起的。该项目的目标是了解这些突变如何改变NMDA受体的结构和功能，并确定潜在的新药物治疗策略。