The Relationship of Obesity with Subclinical Myocardial Injury and Heart Failure

肥胖与亚临床心肌损伤和心力衰竭的关系

• 批准号: 8679114
• 负责人: Chiadi E Ndumele
• 金额: $ 16.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8679114
• 关键词: Adult; Adverse effects; Aging; Animal Model; Atherosclerosis; Award; Baltimore; Biological Assay; Biological Markers; Body Weight; Body Weight decreased; CCL2 gene; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Investigator; Clinical Research; Communities; Data; Data Collection; Deterioration; Development; Development Plans; Diabetes Mellitus; Doctor of Medicine; Doctor of Philosophy; Echocardiography; Epidemiologic Methods; Epidemiology; Event; Fatty acid glycerol esters; Foundations; Functional disorder; Future; Goals; Heart; Heart failure; Hypertension; Incidence; Individual; Inflammatory; Injury; Insulin; Insulin Resistance; Interleukin-6; Knowledge; Leptin; Link; Lipids; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Morbid Obesity; Muscle Cells; Myocardial; Myocardial dysfunction; Myocardium; Obesity; Participant; Patients; Performance; Play; Prevalence; Prevention; Production; Public Health Schools; Recording of previous events; Research; Research Personnel; Risk; Risk Factors; Role; Spectrum Analysis; Structure; Testing; Time; Troponin T; Universities; Visit; Weight; Work; adipokines; adiponectin; bariatric surgery; cardiovascular disorder prevention; cardiovascular risk factor; career; career development; cohort; cytokine; design; experience; follow-up; high risk; indexing; new technology; non-diabetic; novel; novel strategies; prevent; professor; public health relevance; resistin; skills

DESCRIPTION (provided by applicant): Chiadi E. Ndumele, MD, MHS is an Assistant Professor in the Division of Cardiology at Johns Hopkins University. Dr. Ndumele seeks a Mentored Patient-Oriented Research Career Development Award in order to obtain the skills, knowledge and research experience to provide the foundation for a career as an independent investigator in the field of cardiovascular disease prevention. Dr. Ndumele's career development plan includes the completion of a doctorate in Epidemiology at the Johns Hopkins Bloomberg School of Public Health, mentorship from Dr. Josef Coresh, MD, PhD and Dr. Gary Gerstenblith, M.D., and clinical research examining the relationship of obesity with subclinical myocardial injury, myocardial dysfunction and incident heart failure. The specific aims of the research agenda are to: 1) Evaluate the relationship of adult body weight history with the development of myocardial injury, myocardial dysfunction and incident heart failure; 2) Characterize the relationship of myocardial steatosis, evaluated by cardiac MRI spectroscopy, with myocardial injury and dysfunction; 3) To test the longitudinal effects of intentional weight loss before and after bariatric surgery on myocardial injury and dysfunction, and to identify novel risk factors fo myocardial injury in a new cohort of morbidly obese adults. The goals during the award period include developing expertise in the design, performance, analysis and presentation of clinical research, including leading data collection in a new cohort, through mentored research and tailored didactic coursework. Long term goals include developing a career as an independent clinical investigator and developing new approaches for preventing cardiovascular disease related to obesity. Obesity is strongly associated with the development of myocardial dysfunction and heart failure, but the mechanisms underlying this relationship are poorly understood and only partially explained by traditional risk factors. Recent studies demonstrate an independent, graded relationship between obesity and myocardial injury, as indexed by a novel high sensitivity assay for troponin T (hs-cTnT), among individuals without clinical cardiovascular disease that portends a markedly increased risk for the development of heart failure. The proposed research aims to elucidate the factors mediating the relationship of obesity with subclinical myocardial injury, myocardial dysfunction and incident heart failure, with the goal of informing future strategies for cardiovascular risk prediction and prevention among individuals with obesity.

描述（由申请人提供）：Chiadi E. Ndumele，医学博士，MHS是约翰霍普金斯大学心脏病学系的助理教授。Ndumele博士寻求指导以患者为导向的研究职业发展奖，以获得技能，知识和研究经验，为心血管疾病预防领域的独立研究者职业生涯奠定基础。Ndumele博士的职业发展计划包括在约翰霍普金斯彭博公共卫生学院完成流行病学博士学位，并得到医学博士Josef Coresh博士和医学博士加里Gerstenblith博士的指导，以及研究肥胖与亚临床心肌损伤、心肌功能障碍和心力衰竭发病率之间关系的临床研究。本研究的具体目标是：1）评价成人体重史与心肌损伤、心肌功能障碍和心力衰竭发生的关系; 2）通过心脏MRI波谱学评价心肌脂肪变性与心肌损伤和功能障碍的关系; 3）测试减肥手术前后有意减肥对心肌损伤和功能障碍的纵向影响，并在新的病态肥胖成年人队列中确定心肌损伤的新危险因素。获奖期间的目标包括通过指导研究和量身定制的教学课程，在临床研究的设计，性能，分析和演示方面发展专业知识，包括在新的队列中领先的数据收集。长期目标包括发展独立临床研究者的职业生涯，并开发预防与肥胖相关的心血管疾病的新方法。肥胖与心肌功能障碍和心力衰竭的发展密切相关，但这种关系的机制知之甚少，传统的危险因素只能部分解释。最近的研究表明，在没有临床心血管疾病的个体中，肥胖和心肌损伤之间存在独立的分级关系，如肌钙蛋白T（hs-cTnT）的新型高灵敏度检测所示，这些临床心血管疾病预示着心力衰竭的发生风险显著增加。这项研究旨在阐明肥胖与亚临床心肌损伤、心肌功能障碍和心力衰竭的关系， 目标是为肥胖个体的心血管风险预测和预防提供信息。