Translational Drug Abuse Prevention Center

转化药物滥用预防中心

• 批准号: 8693994
• 负责人: PATRICIA CHAMBERLAIN
• 金额: $ 217.51万
• 依托单位: OREGON SOCIAL LEARNING CENTER, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8693994
• 关键词: Address; Adolescent; Adopted; American; Americas; Applications Grants; Area; Behavior; Behavioral; Cellular Phone; Characteristics; Child; Child Welfare; Data; Decision Making; Development; Disadvantaged; Drug abuse; Drug usage; Evidence based intervention; Evidence based practice; Evidence based program; Exposure to; Failure; Family; Female Adolescents; Funding; Future; Goals; Grant; HIV risk; Homelessness; Imprisonment; Individual; Intervention; Investigation; Knowledge; Knowledge Discovery; Lead; Leadership; Learning; Life; Measures; Mental Health; Mentors; Methodology; Methods; Minority; Modeling; National Institute of Drug Abuse; Neurobiology; Oregon; Outcome; Pathway interactions; Pear; Pilot Projects; Policies; Policy Maker; Population; Pregnancy in Adolescence; Prevention Research; Prevention strategy; Preventive Intervention; Process; Psychology; Recording of previous events; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Risk Behaviors; Risk Factors; Science; Scientific Advances and Accomplishments; Scientist; Seeds; Services; Sex Behavior; Shapes; Social Environment; Social Welfare; Societies; System; TNFRSF5 gene; Techniques; Technology; Testing; Time; Training; Training Activity; Translational Research; Universities; Work; Youth; affective neuroscience; base; career; community based service; cost effective; drug abuse prevention; early adolescence; effectiveness trial; efficacy trial; experience; foster care; implementation science; improved; innovation; knowledge base; maltreatment; multidisciplinary; neuroimaging; next generation; novel; physical conditioning; programs; public health relevance; ranpirnase; scale up; social; social neuroscience; statistics; success; systems research; working group

DESCRIPTION (provided by applicant): The purpose of the proposed P50 Center, Translational Drug Abuse Prevention (TDAP), is to serve as a national resource for cutting-edge, multidisciplinary, scientifically innovative and synergistic Type I and II translational prevention research in drug abuse that seeds future research, practice, and policy in the child welfare system (CWS). Children and adolescents with involvement in the CWS, and those adopted following CWS involvement, are at greatly elevated risk for drug use, HIV-risk, and associated problems including delinquency and poor mental health. The TDAP Center will extend our previous work on drug abuse prevention and broaden the reach and impact of our basic and intervention work in this area through an integrated program of research spanning Type I and Type II prevention research that will increase our understanding in three key areas that have direct effects on CWS policy and practice: (1) Understanding of underlying mechanisms and processes associated with exposure to high levels of early life adversity, and specific to risky decision-making in certain social contexts that are common for CWS youth during early adolescence; (2) reducing the high rates of drug use and engagement in HIV-risk behaviors in adolescent girls in the CWS via novel preventive intervention strategies; and (3) identifying methods for implementing extant evidence-based interventions into CWS real-world settings with high fidelity and empirically measuring implementation success/failure in the context of a public child welfare system-initiated reform. The above Research Components will be supported by a Methodology and Statistics Core that will facilitate integrated qualitative and quantitative analyses of the incoming data, as well as integrate the new data with our large existing data resource of CWS studies. A Pilot and Training Core will support the development of small-scale studies designed to lead to innovative, new independent research projects led by early career, and minority researchers in the area of prevention of drug abuse and HIV-risk in the CWS. Finally, an Administrative Core will provide leadership within the Center, interface with an external Advisory Board comprised of experts in CWS leaders and policy makers, and facilitate training and mentoring of Early Career Scientists.

描述（由申请人提供）：拟议的 P50 中心转化药物滥用预防 (TDAP) 的目的是作为药物滥用领域尖端、多学科、科学创新和协同的 I 型和 II 型转化预防研究的国家资源，为儿童福利系统 (CWS) 的未来研究、实践和政策奠定基础。参与 CWS 的儿童和青少年，以及参与 CWS 后被收养的儿童和青少年，吸毒、艾滋病毒风险以及相关问题（包括犯罪和心理健康状况不佳）的风险大大增加。 TDAP 中心将扩展我们之前在药物滥用预防方面的工作，并通过涵盖 I 型和 II 型预防研究的综合研究计划，扩大我们在这一领域的基础和干预工作的范围和影响，这将增加我们对对 CWS 政策和实践有直接影响的三个关键领域的理解：(1) 了解与早期生活中的高水平逆境相关的基本机制和过程，以及特定于 CWS 常见的某些社会背景下的风险决策。 青春期早期的青春期； (2) 通过新的预防干预策略，降低 CWS 中少女的高吸毒率和艾滋病毒危险行为； (3) 确定在 CWS 现实世界环境中以高保真度实施现有循证干预措施的方法，并在公共儿童福利系统发起的改革背景下凭经验衡量实施的成功/失败。上述研究组成部分将得到方法论和统计核心的支持，该核心将促进对传入数据的综合定性和定量分析，并将新数据与我们现有的大型水煤浆研究数据资源相整合。试点和培训核心将支持小规模研究的发展，这些研究旨在引导由早期职业和少数族裔研究人员领导的创新型、新的独立研究项目，涉及 CWS 预防药物滥用和艾滋病毒风险领域。最后，行政核心将在中心内发挥领导作用，与由 CWS 领导者和政策制定者专家组成的外部咨询委员会进行联系，并促进对早期职业科学家的培训和指导。