EKU Lead Faculty Award

EKU 首席教师奖

• 批准号: 8716031
• 负责人: Patrick Joseph Calie
• 金额: $ 3.59万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8716031
• 关键词: Adopted; Animal Model; Applications Grants; Award; Basic Science; Bioinformatics; Biomedical Research; Biometry; Biotechnology; Cell Culture Techniques; Centers of Research Excellence; Clinical; Computer software; Core Facility; DNA; Data Analyses; Data Collection; Defect; Development; Educational workshop; Ensure; Event; Experimental Designs; Faculty; Funding; Gene Expression; Gene Expression Profile; Gene Mutation; Genetic Transcription; Genomic DNA; Genomics; Genotype; Goals; Grant; Health Sciences; Human; Human Resources; Hybridization Array; Individual; Information Sciences; Institution; Internet; Kentucky; Lead; Libraries; Longevity; Manuscripts; MicroRNAs; Microarray Analysis; Molecular; Molecular Profiling; Molecular Target; Mus; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Nursing Faculty; Oligonucleotide Microarrays; Pattern; Preparation; Procedures; Process; Provider; RNA; RNA Splicing; RNA amplification; Research Personnel; Resources; Sample Size; Sampling; Scanning; Schools; Services; Single Nucleotide Polymorphism; Specimen; Technology; Training; Training Programs; Variant; base; data mining; deep sequencing; density; experience; medical schools; next generation sequencing; operation; outreach; rapid growth; tool

The KBRIN-Centralized Core Facility, otherwise known at the Uofl, as the Uofl GG enomics Core Facility, has been operating as a merged INBRE-COBRE operation since 2008, although certain individual components were available separately from either the INBRE or COBRE awards since 2001. Its objectives are to provide state of the art genomic related technologies, including microarray and deep sequencing services to Uofl researchers as well as to investigators in the KBRIN-affiliated institutions and its outreach institutions across the Commonwealth of Kentucky. Its services are centered around the most advanced and comprehensive platforms of high-density oligonucleotide array technologies offered by Affymetrix, Inc. and Agilent, Inc, as well as the next generation sequencing capabilities of the Jon Torrent PGM platform. These platforms allow standardized analyses of RNA or miRNA expression profiles, splice patterns and variations, DNA mutations, and single nucleotide polymorphism profiles. The Facility ensures that all investigators, including clinical faculty and basic science groups, will be able to adopt such state-of-the-art technologies for their investigative goals using clinical specimen, or animal model or cell culture materials. Since its inception, the Facility has experienced a rapid growth in personnel, user numbers and diversity of experimental platforms, allocated space, attendance in training events, and resources for data analysis and mining. It has been an integral part of several funded and/or currently pending individual and multi-investigator Center and Training grant applications, the strongest case for its longevity and its continued utility. The Facility is currently a key component of COBRE 8P20GM103482-10 Center of Biomedical Research Excellence in Molecular Targets (D. Miller, P.l.), COBRE 8P20GM103453-10 Molecular Determinants of Developmental Defects (R. Greene, P.l.), NIGMS- KY-INBRE P20GM103436, KY-IDeA Networks of Biomedical Research Excellence award (N. Cooper, P.l.), and training grant NIEHS T32 ES11564 Uofl EElnvironmental Health Sciences Training Program (D. Hein, P.l.).

KBRIN集中式核心设施，在Uofl也被称为Uofl GG enomics核心设施，自2008年以来一直作为合并的INBRE-COBRE运营，尽管自2001年以来某些单独的组件可以从INBRE或COBRE奖项中单独获得。它的目标是提供最先进的基因组相关技术，包括微阵列和深度测序服务，以Uofl研究人员以及在KBRIN附属机构及其在整个肯塔基州联邦的推广机构的调查人员。它的服务围绕Affytechnology，Inc.提供的高密度寡核苷酸阵列技术的最先进和最全面的平台。和安捷伦公司，以及下一代测序能力的乔恩洪流PGM平台。这些平台允许对RNA或miRNA表达谱、剪接模式和变异、DNA突变和单核苷酸多态性谱进行标准化分析。该机构确保所有研究者，包括临床教师和基础科学团体，将能够采用这些最先进的技术，使用临床标本或动物模型或细胞培养材料进行研究。 自成立以来，该机制在人员、用户数量和实验平台的多样性、分配的空间、培训活动的出席率以及数据分析和挖掘资源方面都经历了快速增长。它一直是几个资助和/或目前正在等待的个人和多个研究中心和培训赠款申请的一个组成部分，这是其寿命和持续效用的最强有力的理由。该设施目前是COBRE 8 P20 GM 103482 -10分子靶向生物医学研究卓越中心的关键组成部分。米勒，P.l.），COBRE 8 P20 GM 103453 -10发育缺陷的分子决定因素（R。格林，P.l.），NIGMS- KY-INBRE P20 GM 103436，KY-IDEA生物医学研究卓越奖网络（N。库珀，P.l.），和培训补助金NIEHS T32 ES 11564 Uofl EElnimental Health Sciences Training Program（D. Hein，P.l.）。