Investigating the role of long non-coding RNAs in neurological disorders using high-resolution transcriptomics

使用高分辨率转录组学研究长非编码 RNA 在神经系统疾病中的作用

• 批准号: nhmrc : GNT1156531
• 负责人: Mr Simon Hardwick
• 金额: $ 41.72万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-long-resolution-transcriptomics/1349216
• 关键词: Investigating; role; long; non; coding

Neurological disorders (eg. Alzheimer's and Parkinson's) have devastating effects, yet little is known about their underlying genetic causes. My research will employ cutting-edge genomic approaches to study gene expression in the human brain at unprecedented resolution. By comparing normal and diseased brains, I will identify and functionally characterise novel genes that play a role in neurological dysfunction, which could ultimately be used as therapeutic targets and/or biomarkers for disease.

神经系统疾病（例如阿尔茨海默氏症和帕金森氏症）具有破坏性影响，但对其潜在的遗传原因知之甚少。我的研究将采用尖端的基因组方法以前所未有的分辨率研究人脑中的基因表达。通过比较正常和患病的大脑，我将识别和功能表征在神经功能障碍中发挥作用的新基因，这些基因最终可以用作疾病的治疗靶点和/或生物标志物。