Investigating the role of long non-coding RNAs in neurological disorders using high-resolution transcriptomics

神经性疾病(如阿尔茨海默氏症和帕金森氏症)具有毁灭性的影响，但人们对其潜在的遗传原因知之甚少。我的研究将使用尖端基因组学方法，以前所未有的分辨率研究人类大脑中的基因表达。通过比较正常和患病的大脑，我将识别和描述在神经功能障碍中发挥作用的新基因，这些基因最终可能被用作治疗目标和/或疾病的生物标记物。

Neurological disorders (eg. Alzheimer's and Parkinson's) have devastating effects, yet little is known about their underlying genetic causes. My research will employ cutting-edge genomic approaches to study gene expression in the human brain at unprecedented resolution. By comparing normal and diseased brains, I will identify and functionally characterise novel genes that play a role in neurological dysfunction, which could ultimately be used as therapeutic targets and/or biomarkers for disease.