PS11-003 Minority AIDS Research Initiative

PS11-003 少数民族艾滋病研究计划

• 批准号: 8784076
• 负责人: Yannine Amanda Estrada
• 金额: $ 28.37万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784076
• 关键词: PS11; 003; Minority; AIDS; Research

DESCRIPTION (provided by applicant): The proposed study aims to address health disparities between Hispanic and non-Hispanic whites, particularly as it relates to HIV and drug use in Hispanic adolescents. This goal will be accomplished by two aims: AIM I is to develop an Internet-based version of the face-to-face Familias Unidas intervention (hereafter referred to as Internet-Based Familias Unidas); and AIM II is to evaluate the efficacy of Internet-Based Familias Unidas, relative to both face-to-face Familias Unidas and a community practice control condition, in preventing unprotected sexual behavior and drug use in a community sample of Hispanic adolescents living in Miami-Dade County. 270 Hispanic adolescents recruited from three high schools will be randomized using an urn design to one of three conditions: Internet-Based Familias Unidas, face-to-face Familias Unidas or Community Practice. Face-to-face Familias Unidas, a Hispanic-specific, family- centered intervention, has been found efficacious, relative to control conditions, in preventing adolescent unprotected sexual behavior and drug use in two randomized clinical trials (Pantin et al., 2009; Prado et al., 2007). Hierarchical Linear Modeling (HLM) will be used to test: (H1) Internet-Based Familias Unidas and face-to-face Familias Unidas will be more efficacious than Community Practice Control in preventing adolescent unprotected sexual behavior over time; (H2) Internet-Based Familias Unidas and face-to-face Familias Unidas will be more efficacious than Community Practice Control in preventing adolescent drug use over time; (H3) Internet-Based Familias Unidas will be more efficacious than face-to-face Familias Unidas in preventing adolescent unprotected sexual behavior over time; and (H4) Internet-Based Familias Unidas will be more efficacious than face-to-face Familias Unidas in preventing adolescent drug use over time. Additionally HLM will be used to determine whether (H1a) the effect of Internet-Based Familias Unidas and face-to-face Familias Unidas on adolescent unprotected sexual behavior will be partially mediated by family functioning; (H2a) the effect of Internet-Based Familias Unidas and face-to- face Familias Unidas on adolescent drug use will be partially mediated by family functioning; (H3a) the effect of Internet-Based Familias Unidas on unprotected sexual behavior will be partially mediated by participation rates; and (H4a) the effect of Internet-Based Familias Unidas on adolescent drug use will be partially mediated by participation rates.

描述（由申请人提供）：拟议的研究旨在解决西班牙裔和非西班牙裔白人之间的健康差异，特别是因为它涉及西班牙裔青少年的艾滋病毒和药物使用。这一目标将通过两个目标来实现：目标一是开发一个基于互联网的“家庭团结”面对面干预版本（以下简称“互联网家庭联盟”）;目的二是评估基于互联网的家庭团结的功效，相对于面对面的家庭团结和社区实践控制条件，在迈阿密-戴德县的西班牙裔青少年社区样本中预防无保护的性行为和吸毒。从三所高中招募的270名西班牙裔青少年将使用瓮设计随机分配到三种条件之一：基于互联网的Familias Unidas、面对面的Familias Unidas或社区实践。在两项随机临床试验中，已经发现面对面的Familias Unidas，一种西班牙裔特异性的、以家庭为中心的干预，相对于对照条件，在预防青少年无保护的性行为和药物使用方面是有效的（Pantin等人，2009;普拉多等人，2007年）。 将使用分层线性模型检验：（H1）随着时间的推移，基于互联网的家庭联盟和面对面的家庭联盟在预防青少年无保护性行为方面将比社区实践控制更有效;（H2）随着时间的推移，基于互联网的家庭联盟和面对面的家庭联盟在预防青少年吸毒方面将比社区实践控制更有效;（H3）随着时间的推移，基于互联网的Familias Unidas在预防青少年无保护性行为方面将比面对面的Familias Unidas更有效;以及（H4）随着时间的推移，基于互联网的Familias Unidas在预防青少年吸毒方面将比面对面的Familias Unidas更有效。此外，HLM将用于确定（H1 a）基于互联网的家庭和面对面的家庭对青少年无保护性行为的影响是否部分由家庭功能介导;（H2 a）基于互联网的家庭和面对面的家庭对青少年吸毒的影响是否部分由家庭功能介导;（H3 a）互联网家庭对无保护性行为的影响部分由参与率介导;（H4 a）互联网家庭对青少年吸毒的影响部分由参与率介导。