Image-Guided Photodynamic Therapy of Lung Cancer

影像引导肺癌光动力治疗

基本信息

批准号：
8774361
负责人：
CHUKWUMERE E. NWOGU
金额：
$ 19.09万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8774361
关键词：
Abbreviations Accounting Adjuvant Adjuvant Chemotherapy Animal Model Animals Area Award Cancer Etiology Cancer Model Canis familiaris Cessation of life Chronic Obstructive Airway Disease Clinic Clinical Clinical Trials Colon Comorbidity Detection Development Diagnosis Diagnostic Neoplasm Staging Disease Distant Drainage procedure Excision FDA approved Family suidae Fluorescence Funding Goals Human Image Invaded Ipsilateral Label Laboratories Lesion Light Local Therapy Lung Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Mammary Neoplasms Microscopic Modality Modeling Morbidity - disease rate Neoplasm Metastasis Nodal Non-Small-Cell Lung Carcinoma Operative Surgical Procedures Outcome Patients Phase Photochemotherapy Photosensitizing Agents Porfimer Sodium Positron-Emission Tomography Primary Neoplasm Radiation therapy Radioactive Radioisotopes Radiosurgery Recurrence Research Resectable Resected Residual Tumors Respiratory physiology SCID Mice Skin Structure Structure of lymph node of thorax Structure of parenchyma of lung Surgical margins Therapeutic Tobacco use Toxic effect Translating Treatment Efficacy Tumor stage United States Woman Xenograft procedure absorption analog base bone chemotherapy chlorophyll a compare effectiveness disorder control effective therapy falls fluorescence imaging fluorodeoxyglucose improved lymph nodes meetings men novel novel therapeutics operation pre-clinical public health relevance tumor

项目摘要

DESCRIPTION (provided by applicant): This Exploratory/Developmental Research Award will provide the funds for Drs. Nwogu and Pandey to study a novel "Multifunctional Agent" for image guided (PET/fluorescence) surgery and photodynamic therapy (PDT) in preclinical animal models. Translating this to the clinic will markedly change the treatment paradigm for locoregional non-small cell lung cancer and result in improved outcomes for patients. Detection of occult lymph node disease will be enhanced and intraoperative adjuvant photodynamic therapy can be accomplished. Additionally, patients whose comorbidities preclude surgical resection can have a repeatable, effective therapy (PDT). In order to achieve our imaging and therapeutic goals, this study is divided into following aims: 1) Compare the effectiveness of 124I-PS2 and 18F-Fluorodeoxyglucose (FDG) in imaging of lung tumors and lymph node metastases using an orthotopic lung cancer model in SCID mice. 2) Compare the effectiveness of photodynamic therapy using PS2 and Porfimer Sodium (Photofrin(R)) in human NSCLC xenografts established subcutaneously in SCID mice. On completion of the proposed project, we plan to study the therapeutic efficacy of this novel multifunctional radioisotope in a larger animal orthotopic lung cancer model such as dogs or pigs. PDT to both the lung tumor and its nodal drainage basin will be better refined in such larger animal models. This will be followed by phase I human clinical trials. The target subset of patients to whom this would be applicable include those with resectable primary NSCLC who are undergoing surgery to resect lesions that are larger than 3 cm or invading surrounding structures, or any patients with clinical ipsilateral thoracic lymph node disease. A local therapy to the regional lymph node basin and surgical margins that can be delivered with minimal morbidity immediately following resection of a primary tumor and its draining lymph nodes could dramatically reduce disease recurrence and improve long term survival. This is a novel therapeutic paradigm.

描述（由申请人提供）：该探索/发展研究奖将为DRS提供资金。 Nwogu和Pandey在临床前动物模型中研究了一种用于图像指导（PET/荧光）手术和光动力疗法（PDT）的新型“多功能药物”。将其转化为诊所将显着改变局部非小细胞肺癌的治疗范例，并改善患者的预后。可能会增强神秘淋巴结疾病的检测，并可以完成术中佐剂光动力疗法。此外，合并症的患者排除外科手术切除术可以进行可重复的有效治疗（PDT）。为了实现我们的成像和治疗目标，本研究分为以下目的：1）比较124i-PS2和18F-氟脱氧葡萄糖（FDG）在Scid小鼠中使用正规肺癌模型的肺部肿瘤和淋巴结转移成像的有效性。 2）使用PS2和Porfimer钠（Photofrin（R））在SCID小鼠中皮下建立的人NSCLC异种移植物中比较光动力疗法的有效性。拟议项目完成后，我们计划研究这种新型多功能放射性同位素在大型动物原位肺癌模型（例如狗或猪）中的治疗功效。在如此较大的动物模型中，PDT对肺部肿瘤及其淋巴结排水盆地都将更好地完善。随后将进行I期人类临床试验。适用的患者的目标子集包括那些正在接受手术的可切除原发性NSCLC的患者，以切除大于3 cm或入侵周围结构的病变，或任何患有同侧胸腔淋巴结淋巴结疾病的患者。在切除原发性肿瘤及其排干淋巴结后，可以用最小的发病率对局部淋巴结盆地和手术缘的局部疗法，可以大大降低疾病复发并改善长期存活率。这是一种新颖的治疗范式。