Investigating the therapeutic potential of FTY720 for Human African Trypanosomiasis

研究 FTY720 对非洲人类锥虫病的治疗潜力

• 批准号: nhmrc : 1067728
• 负责人: Dr Graeme Stevenson
• 金额: $ 43.59万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-therapeutic-potential-african-trypanosomiasis/455321
• 关键词: Investigating; therapeutic; potential; FTY720; Human

FTY720, is a drug currently used to treat multiple sclerosis, which we have shown is also be able to kill the parasite responsible for African sleeping sickness, Trypanosomes. We aim to identify the target the drug acts on in the parasite to have its affect. Our objective is to improve the activity further by chemical modification to produce a potent, orally available and well characterised, non-toxic drug suitable for preclinical development.

FTY720是一种目前用于治疗多发性硬化症的药物，我们已经证明，它也能够杀死导致非洲昏睡病的寄生虫-锥虫。我们的目标是确定这种药物作用于寄生虫的靶点，使其发挥作用。我们的目标是通过化学修饰进一步提高活性，以生产一种有效的、口服可用的、特性良好的、适合临床前开发的无毒药物。