FASEB SRC on Regulation and Function of Small GTPases

描述(由申请者提供)：本次会议将聚焦于“小GTP酶的调节和功能”。这是FASEB致力于这一主题的一系列夏季研究会议中的第11次，在过去的20年里，它一直是该领域“必去”的会议。对这次会议的持久承诺在于它继续专注于解开复杂的信号转导途径，并使用最先进的技术和精致的模型系统来做到这一点。小分子GTP结合蛋白(如Ras、Rac、Rho、CDC42、Rab、Rap、Rheb和Ral)调控多种细胞过程，包括增殖、迁移、发育、基因表达和新陈代谢。此外，这些GTP酶和下游效应通路的放松调控是许多人类疾病的基础，包括癌症、糖尿病、血管疾病和发育障碍。RAS是小的GTP酶超家族的创始成员，是人类癌症中最常见的突变癌基因，与其效应因子一起，是药物发现的主要靶点。在过去的十年中，许多其他家族成员被证明是癌症和转移的基础(RhoA，rac1，Rab5，Rheb，Rala)。会议的主要目标是促进不同研究人员之间思想的交叉授粉，这些研究人员横跨基本生化机制、细胞和组织生物学以及翻译研究。由于Ras、Rac、Rab、Rho、Rheb和Ral在癌症和转移中扮演着特别重要的角色，因此本次会议将以强烈的癌症主题为基础。然而，我们也将强调一些生物学领域(新陈代谢、神经生物学、发育生物学)的进展，以确保我们利用和学习在其他重要相关领域的发现。为了加强思想交流，会议将围绕生物主题安排，但包括不同的方法和模式系统。拥有广泛和互补专业知识的个人并列在一起，将确保出现新的想法，并建立未来的合作。会议将于2012年6月2日至7日在科罗拉多州的斯普林斯举行，这是促进非正式讨论和支持协作环境的理想地点。来自美国、欧洲、新加坡和日本的35位特邀演讲者(均已确认)。我们将特别关注下一代研究人员的参与，16场讲座将由刚刚开始独立职业生涯的学生、博士后或研究人员进行。 将举行两次讨论，唯一的目的是鼓励和建议下一代撰写论文和获得拨款。招贴会将进一步增加介绍和讨论未公布数据的机会。特别注意吸纳妇女以及年轻和少数族裔调查人员。虽然这次会议一直都有一个包容的气氛，我们也将为少数族裔和女性申请者在其职业生涯的不同阶段提供8个旅行奖励。这一举措将在申请中详细说明。好了！

DESCRIPTION (provided by applicant): This conference will focus on the 'Regulation and Function of Small GTPases'. It is the eleventh in a series of FASEB summer research conferences devoted to this topic and it has been the "must go to" meeting in the field for the last 20 years. The enduring commitment to this meeting lies in its continued focus on unravelling complex signal transduction pathways and using state-of-the art technology and refined model systems to do so. Small GTP-binding proteins (e.g. Ras, Rac, Rho, Cdc42, Rab, Rap, Rheb and Ral) regulate diverse cellular processes including proliferation, migration, development, gene expression, and metabolism. Moreover, the deregulation of these GTPases and downstream effector pathways underlies many human diseases, including cancer, diabetes, vascular disease and developmental disorders. The founding member of the small GTPase superfamily, Ras, is the most commonly mutated oncogene in human cancers and, together with its effectors, is a major target for drug discovery. Over the last decade, many other family members have been shown to be fundamental in cancer and metastasis (RhoA, Rac1, Rab5, Rheb, RalA). The principal objective of the meeting is to stimulate cross-pollination of ideas among a diverse group of researchers that spans basic biochemical mechanisms, cell and tissue biology, and translational research. Because Ras, Rac, Rab, Rho, Rheb and Ral play a particularly important role in cancer and metastasis, there will be a strong cancer theme underlying this meeting. However, we will also highlight progress from a number of biological fields (metabolism, neurobiology, developmental biology) to ensure that we are leveraging and learning from discoveries made in other important related fields. To enhance the exchange of ideas, the sessions will be arranged around biological themes, but included varied approaches and model systems. The juxtaposition of individuals with wide-ranging and complementary expertise will ensure that new ideas emerge and future collaborations are established. The conference will be held June 2-7, 2012, in Steamboat Springs, Colorado, which is an ideal location for fostering informal discussions and supporting a collaborative environment. There are 35 invited speakers from the United States, Europe, Singapore and Japan (all of which are confirmed). We will particularly focus on engaging the next generation of researchers, and 16 talks will be given by students, post-docs or investigators just starting their independent career. Two discussion sessions will be held with the sole purpose of encouraging and advising the next generation on writing papers and getting grants. Poster sessions will further enhance the opportunity for the presentation and discussion of unpublished data. Specific attention has been paid to inclusion of women, and of young and minority investigators. While this meeting has always had an inclusive atmosphere we will also be offering 8 travel awards to minority and female applicants at various stages of their careers. This initiative will be detailed in the application. !