Investigating the use of metformin for the prevention of endometrial cancer

研究二甲双胍预防子宫内膜癌的用途

• 批准号: nhmrc : 1061800
• 负责人: Kristy Brown
• 金额: $ 45.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-use-metformin-endometrial-cancer/454933
• 关键词: Investigating; use; metformin; prevention; endometrial

Endometrial (uterine) cancer affects approximately 3% of women. Obesity and oestrogen exposure are risk factors for this cancer. A novel approach to prevent endometrial cancer would be to oppose the effects of insulin and oestrogen on endometrial cell growth. This study will investigate whether metformin, commonly used to treat diabetes, blocks cellular pathways by which oestrogen and insulin stimulate endometrial cell growth, and thus evaluate the possibility that metformin might be useful in preventing endometrial cancer.

子宫内膜（子宫）癌影响约3%的妇女。肥胖和雌激素暴露是这种癌症的危险因素。一种预防子宫内膜癌的新方法是对抗胰岛素和雌激素对子宫内膜细胞生长的影响。本研究将调查二甲双胍，通常用于治疗糖尿病，是否阻断雌激素和胰岛素刺激子宫内膜细胞生长的细胞途径，从而评估二甲双胍可能有助于预防子宫内膜癌的可能性。