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Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env

Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env
聚糖修饰对受体结合位点的影响
批准号：
8513893
负责人：
Shiu Hu
金额：
$93.78万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
已结题
起止时间：
至 2016-07-31
来源：
https://reporter.nih.gov/project-details/8513893
关键词：
AIDS VaccinesAffinityAntibodiesAntibody FormationAntigensBindingBinding SitesC-terminalEpitopesExcisionExhibitsGoalsHIVHIV Envelope Protein gp120HIV-1ImmunizationInfectionLeadLinkMacacaMasksMediatingModelingModificationPolysaccharidesPropertySiteTestingVaccine ResearchVirusbasedesignimmunogenicityinsightmacrophagemutantneutralizing antibodyprotective efficacyreceptorreceptor bindingsimian human immunodeficiency virusstem

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中文摘要
翻译
能诱导抗多种人血吸虫分离株的中和抗体（NtAb）的免疫原的设计 免疫缺陷病毒（HIV）仍然是艾滋病疫苗研究中未达到的目标。多种因素可能 导致难以广泛产生抗HIV的NtAb。这些包括构象掩蔽 受体和辅助受体结合位点（BS）周围的保守表位以及聚糖的封闭 部分（
英文摘要
Design of immunogens capable of inducing neutralizing antibodies (NtAb) against diverse isolates of human immunodeficiency virus (HIV) remains an unmet goal in AIDS vaccines research. Multiple factors may contribute to the difficulty in generating broadly NtAb against HIV. These include conformational masking of the conserved epitopes around the receptor and coreceptor binding sites (bs), as well as occlusion by glycan moieties (
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Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env
Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env
Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env
Effects of glycan modification on receptor binding site & immunogen of HIV-1 Env
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