Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer’s disease pathology

研究 2 型糖尿病与阿尔茨海默病病理学之间的潜在机制

• 批准号: nhmrc : 1105698
• 负责人: A/Pr Giuseppe Verdile
• 金额: $ 48.13万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-underlying-mechanisms-disease-pathology/662847
• 关键词: Investigating; underlying; mechanisms; linking; Type

With type-2 diabetes representing a major risk factor for neurodegenerative diseases such as Alzheimer's disease, it is important to understand the underlying mechanisms. This project will provide significant insight into how T2D impacts the brain with a focus on how deficiencies in brain inuslin signaling drives neurodegeneration. We will also evaluate novel inuslin like molecules at improving brain insulin siganling and preventing or slowing down the neurodegenerative process.

由于2型糖尿病是阿尔茨海默病等神经退行性疾病的主要危险因素，因此了解其潜在机制非常重要。该项目将提供T2D如何影响大脑的重要见解，重点是大脑inuslin信号传导的缺陷如何驱动神经退行性变。我们还将评估新型胰岛素样分子在改善脑胰岛素信号传导和预防或减缓神经退行性过程中的作用。