Colorado PETAL Clinical Center

描述（由申请人提供）：大约50年前，Tom Petty博士和他的外科同事在科罗拉多大学发现了12例具有相似临床症状的患者：严重低氧血症、胸部X线片上的双侧浸润和静态肺顺应性降低。这些患者的临床特征作为病例系列发表在《柳叶刀》上，并作为急性呼吸窘迫综合征（ARDS）的初步描述。这一开创性的发现开启了丹佛ARDS研究的漫长而富有成效的历史。自1994年成立以来，我们一直是ARDS网络的成员。我们的多学科和协作的重症监护研究小组在进行高质量的多中心临床试验方面经验丰富。因此，我们一直是超过19年的顶级注册ARDS网络网站之一。科罗拉多大学的急诊医学系是急诊医学最早的住院医师培训项目之一，并且仍然是该国最受重视的培训项目之一。在过去的十年中，他们的校外资金迅速增长，特别是在重症监护研究领域。肺科学和重症监护医学部和急诊医学部在以患者为导向和研究计划方面建立了有效合作的记录。在这个ARDS网络研究基础设施的基础上，我们将创建一个综合的重症监护和急诊医学临床中心，以有效地进行预防和早期治疗急性肺损伤的临床试验。该科罗拉多PETAL临床中心将超越我们的入组义务;在方案合规性、数据采集和监管责任方面保持卓越的质量;积极参与并促进后续的 指导和其他PETAL委员会的职责;并有助于改善对ARDS患者和有ARDS风险患者的护理。

DESCRIPTION (provided by applicant): Almost 50 years ago, Dr. Tom Petty and his surgical colleagues identified 12 patients at the University of Colorado with similar clinical symptoms: severe hypoxemia, bilateral infiltrates on chest radiograph, and diminished static pulmonary compliance. The clinical features of these patients were published as a case series in the Lancet and serve as the initial description of the acute respiratory distress syndrome (ARDS). This seminal discovery launched a long and productive history of ARDS research in Denver. We have been a member of the ARDS Network since its inception in 1994. Our multi-disciplinary and collaborative critical care research group is experienced in conducting high quality multi-center clinical trials. As a result, we have always been one of the top enrolling ARDS Network sites for over 19 years. The University of Colorado's Department of Emergency Medicine was one of the first residency training programs in Emergency Medicine and remains one of most highly regarded training programs in the country. Their extramural funding has grown rapidly in the past decade especially in the area of critical care research. The Division of Pulmonary Sciences and Critical Care Medicine and the Department of Emergency Medicine have an established record of effective collaborations in both patient-oriented and research initiatives. Building on this ARDS Network research infrastructure, we will create an integrated Critical Care and Emergency Medicine clinical center to effectively conduct clinical trials for the prevention and early treatment of acute lung injury. This Colorado PETAL Clinical Center will exceed meet our enrollment obligations; maintain excellence in the quality of protocol compliance, data acquisition, and regulatory responsibilities; actively participate and contribute to the subsequent responsibilities of the steering and other PETAL committees; and contribute to the improved care of patients with and at risk for ARDS.