Colorado PETAL Clinical Center

描述(申请人提供)：大约50年前，Tom Petty博士和他的外科同事在科罗拉多大学发现了12名有类似临床症状的患者：严重的低氧血症，胸片上的双侧浸润性，以及静态肺顺应性降低。这些患者的临床特征作为病例系列发表在《柳叶刀》上，并作为急性呼吸窘迫综合征(ARDS)的初步描述。这一开创性的发现开启了丹佛ARDS研究的漫长而富有成效的历史。自1994年ARDS网络成立以来，我们一直是该网络的成员。我们的多学科协作重症监护研究团队在进行高质量的多中心临床试验方面经验丰富。因此，19年来，我们一直是ARDS网络注册人数最多的网站之一。科罗拉多大学急诊医学系是首批急诊医学住院医师培训项目之一，至今仍是全美最受推崇的培训项目之一。它们的外部资金在过去十年中迅速增长，特别是在危重护理研究领域。肺科学和危重病医学司和急诊医学部在以病人为导向和研究举措方面都有有效合作的既定记录。在ARDS网络研究基础设施的基础上，我们将创建一个综合重症监护和急诊医学临床中心，以有效地进行急性肺损伤预防和早期治疗的临床试验。科罗拉多州花瓣临床中心将超过我们的注册义务；在协议遵从性、数据获取和监管责任方面保持卓越的质量；积极参与并为后续的 指导委员会和其他花瓣委员会的职责；并有助于改善ARDS患者和有ARDS风险的患者的护理。

DESCRIPTION (provided by applicant): Almost 50 years ago, Dr. Tom Petty and his surgical colleagues identified 12 patients at the University of Colorado with similar clinical symptoms: severe hypoxemia, bilateral infiltrates on chest radiograph, and diminished static pulmonary compliance. The clinical features of these patients were published as a case series in the Lancet and serve as the initial description of the acute respiratory distress syndrome (ARDS). This seminal discovery launched a long and productive history of ARDS research in Denver. We have been a member of the ARDS Network since its inception in 1994. Our multi-disciplinary and collaborative critical care research group is experienced in conducting high quality multi-center clinical trials. As a result, we have always been one of the top enrolling ARDS Network sites for over 19 years. The University of Colorado's Department of Emergency Medicine was one of the first residency training programs in Emergency Medicine and remains one of most highly regarded training programs in the country. Their extramural funding has grown rapidly in the past decade especially in the area of critical care research. The Division of Pulmonary Sciences and Critical Care Medicine and the Department of Emergency Medicine have an established record of effective collaborations in both patient-oriented and research initiatives. Building on this ARDS Network research infrastructure, we will create an integrated Critical Care and Emergency Medicine clinical center to effectively conduct clinical trials for the prevention and early treatment of acute lung injury. This Colorado PETAL Clinical Center will exceed meet our enrollment obligations; maintain excellence in the quality of protocol compliance, data acquisition, and regulatory responsibilities; actively participate and contribute to the subsequent responsibilities of the steering and other PETAL committees; and contribute to the improved care of patients with and at risk for ARDS.