Investigation of Cardiac Stem Cell Regenerative Capabilities and their Enhancement by Manipulation of Telomerase Reverse Transcriptase

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Heart failure rates are increasing exponentially in Australia and worldwide. One in two people diagnosed with severe heart failure will die within one year of diagnosis. This burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. This limitation could be overcome by stimulating newly discovered stem cell populations residing within the adult heart itself. This project investigates ways to harness and enhance the power of these stem cells.