Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
基本信息
- 批准号:8827934
- 负责人:
- 金额:$ 25.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-11-20 至 2018-10-31
- 项目状态:已结题
- 来源:
- 关键词:AffinityAfricaAnimal DiseasesAnimalsAntiviral AgentsAntiviral ResponseAsiaBindingBiochemicalBunyaviridaeCentral AsiaCleaved cellCongoCrimean Hemorrhagic FeverCrimean-Congo Hemorrhagic Fever VirusDevelopmentDiseaseDisease OutcomeDistressDown-RegulationEconomicsElementsEndogenous RetrovirusesEngineeringEuropeFDA approvedFamilyFar EastFeverGenesGenomeGoalsHemorrhageHomologous GeneHumanHuman UbiquitinImmune responseImmune systemIn VitroInflammatoryInterferon SuppressionInterferonsMeasuresMiddle EastMono-SMusNairobi Sheep DiseaseNairobi sheep disease virusNairovirusNatural ImmunityPeptide HydrolasesPhylogenetic AnalysisPlayPolyubiquitinPost-Translational Protein ProcessingProtease DomainProteinsRNARNA-Directed RNA PolymeraseRecombinantsRelative (related person)ReportingRiskRoentgen RaysRoleRouteRussiaSeveritiesSimulateSpecificityStructureSubstrate SpecificitySystemTherapeuticThunderclap HeadachesTicksUbiquitinUbiquitinationUnited StatesVaccinesVariantViralViral Hemorrhagic FeversVirulenceVirulence FactorsVirusbasecytokinehealth economicshuman diseasein vitro activityin vivoinsightmortalityovarian neoplasmparticlepositional cloningprophylacticprostrationpublic health relevanceresearch studytraffickingtransmission processvector
项目摘要
Summary/Abstract
Crimean-Congo hemorrhagic fever virus (CCHFV) is a ssRNA (-) nairovirus that produces fever,
prostration, and severe hemorrhages in humans. Fatality rates associated with CCHFV range from 5-
80% based on phylogenetic variation of the virus, transmission route, and different treatment facilities.
Originally identified in Russia and the Congo, CCHFV has rapidly spread across large sections of
Europe, Asia, and Africa. Recently, U.S. citizen traffic has increased substantially to the regions
endemic with CCHFV, specifically South Central Asia. As a result, there is a substantial risk for
transmission of CCHFV and/or its tick vector to the United States. Intriguingly, CCHFV is not the only
nairovirus that threatens the public. Nairobi Sheep Disease virus (NSDV) as well as nairoviruses
Hazara, Dugbe and Erve can cause human disease of varying severity and economic distress.
Currently, there is no vaccine or prophylactic available for treatment of CCHF or other any other
nairovirus related diseases. Recent reports have identified a viral homologue of the ovarian tumor
protease (vOTU) located within the nairovirus genome and implicated its possible involvement in
down-regulation of the Interferon type 1 immune response through cleavage of post-translational
modifying proteins ubiquitin (Ub) and Ub-like interferon-simulated gene 15 (ISG15). As a result, it has
been suggested to be a virulence factor. This proposal will determine whether dual deubiquitinating
and deISGylating activities are conserved functions of this subclass of proteases in vitro and in vivo.
Additionally, these experiments will gain insight into their mechanism of recognition for Ub and ISG15
allowing greater predictability of currently unknown vOTUs. The proposal will also seek to evaluate a
potential correlation between the in vitro activity/substrate specificity of these nairovirus vOTUs and
overall virulence of the nairoviruses in question. The resulting information will also provide critical
insight into the role of vOTUs play in viruses that may ultimately have practicality in the development
of prophylactics targeting vOTUs.
摘要/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Scott Dusan Pegan其他文献
Scott Dusan Pegan的其他文献
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{{ truncateString('Scott Dusan Pegan', 18)}}的其他基金
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10120003 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10673300 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10689136 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10774369 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10480951 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10264937 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
10757071 - 财政年份:2020
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
9171939 - 财政年份:2013
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
8614887 - 财政年份:2013
- 资助金额:
$ 25.11万 - 项目类别:
Origin of the innate immunity suppression caused by nairovirus' protease activity
内罗病毒蛋白酶活性引起先天免疫抑制的起源
- 批准号:
9044012 - 财政年份:2013
- 资助金额:
$ 25.11万 - 项目类别:
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