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FASEB SRC on Folic Acid, Vitamin B12 and One Carbon Metabolism

FASEB SRC 关于叶酸、维生素 B12 和一碳代谢

基本信息

批准号：
8781114
负责人：
SALLY P STABLER
金额：
$ 4万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8781114
关键词：
Animal Model Applications Grants Area Autistic Disorder Award Basic Science Behavioral Betaine Biology Carbon Cellular Stress Charge Clinical Clinical Medicine Collaborations Colorado Congenital Abnormality Cystathionine beta-Synthase Cysteine Desulfhydrase Data Deficiency Diseases Development Diagnostic tests Discipline Disease Doctor of Philosophy Environment Enzymes Epidemiologist Folate Folic Acid Food Fostering Funding Genes Goals Health Health Policy Homocysteine Homocystine Human Hydrogen Sulfide Hypertension International Investigation Knock-out Knowledge Laboratories Lead Liver diseases Maternal and Child Health Measures Medicine Mentors Metabolic Metabolic Pathway Metabolism Molecular Neural tube Neurologic Nutritional Pathway interactions Pharmacologic Substance Postdoctoral Fellow Prize Public Health Public Policy Recording of previous events Research Research Personnel Risk Role Schedule Scientist Senior Scientist Site Testing Therapeutic Training Transgenic Animals Translations Travel Vascular Dementia Vascular Diseases Vitamin B 12 Vitamin B Complex Vitamin B6 Vitamin Deficiency Vitamins Work abstracting base career enzyme pathway fortification health organization human disease innovation interest lectures meetings novel nutrition planetary Atmosphere posters programs public health relevance receptor symposium transmethylation unpublished works vitamin therapy

项目摘要

DESCRIPTION (provided by applicant): This proposal is for partial funding of a FASEB SRC conference on Folic Acid, Vitamin B12 and One Carbon Metabolism to be held in Steamboat Springs, Colorado in August, 2014. This conference has a long successful history and has been held every 2 years since 1986. It brings together scientists interested in the role of these essential B vitamins in human health and disease. This conference is unique because it is attended by scientists from many disciplines and areas of biology and medicine united in their interest in these vitamin dependent pathways. For example, PhD scientists studying folate-dependent enzymes and molecular biologists studying the genes important in this field meet for 5 days with MD clinicians studying vitamin deficiency diseases, clinical chemists evaluating diagnostic testing, and public health scientists charged with developing nutrition related public policy. This group was involved previously in important public health measures such as the folate food fortification mandate and investigations of the benefits of folate based vitamin therapy in vascular disease and dementia. The proposed program presents new information on these vitamin-related enzymes and metabolic pathways in liver diseases, hypertension, autism, neural tube and other birth defects. Information about benefits and possible risks with the mandated folate food fortification will be presented. The importance of folate and vitamin B12 nutrition in maternal-child health will be discussed. The proposed conference is an excellent training environment for junior scientists because the chance to present their latest work at a national meeting among experts in this area of metabolism will help them find collaborations, refine their scientific direction and practice lecturing in an informal atmosphere. The conference provides many opportunities to interact between attendees at meals, breaks, poster sessions and outdoor recreational facillities. These interactions have the potential to lead to basic scienc informed innovations in public health.

描述（由申请人提供）：本提案是为2014年8月在科罗拉多州蒸汽船泉举行的叶酸、维生素B12和一碳代谢FASEB SRC会议提供部分资金。该会议历史悠久，自1986年以来每两年举办一次。它汇集了对这些必需的B族维生素在人类健康和疾病中的作用感兴趣的科学家。这次会议是独一无二的，因为它由来自生物学和医学的许多学科和领域的科学家参加，他们对这些维生素依赖途径感兴趣。例如，研究叶酸依赖性酶的博士科学家和研究该领域重要基因的分子生物学家与研究维生素缺乏症的医学博士临床医生、评估诊断测试的临床化学家以及负责制定营养相关公共政策的公共卫生科学家会面5天。该小组以前参与了重要的公共卫生措施，如叶酸食品强化授权和基于叶酸的维生素治疗血管疾病和痴呆的益处的调查。该计划提出了有关这些维生素相关酶和肝脏疾病、高血压、自闭症、神经管和其他出生缺陷代谢途径的新信息。将介绍强制性叶酸食品强化的益处和可能的风险。将讨论叶酸和维生素B12营养对母婴健康的重要性。提议的会议为年轻科学家提供了一个极好的培训环境，因为有机会在新陈代谢领域专家的全国会议上展示他们的最新工作，将有助于他们找到合作，完善他们的科学方向，并在非正式的气氛中练习演讲。会议在用餐、休息、海报会议和户外娱乐设施上为与会者提供了许多互动的机会。这些相互作用有可能导致公共卫生领域基于基础科学的创新。