Stellenbosch University Clinical Trials Unit (SUN-CTU)

斯泰伦博斯大学临床试验中心 (SUN-CTU)

• 批准号: 8784177
• 负责人: Mark Fredric Cotton
• 金额: $ 115.55万
• 依托单位: STELLENBOSCH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-15 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784177
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Address; Adherence; Adolescent; Adult; Affect; Age; Antitubercular Agents; Applied Research; Biological Markers; Caring; Case Study; Child; Childhood; Cities; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Unit; Communicable Diseases; Communities; Comorbidity; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Drug Kinetics; Drug resistance in tuberculosis; Epidemic; Faculty; Family; Funding Agency; Gender; HIV; HIV Infections; HIV prevention trial; Health Sciences; Hepatitis B; Hepatitis E; High Prevalence; Household; IMPAACT; Incidence; Individual; Infant; Infection; International; Laboratories; Link; Low Birth Weight Infant; Malignant neoplasm of cervix uteri; Measures; Medicine; Multidrug-Resistant Tuberculosis; National Institute of Allergy and Infectious Disease; Participant; Pharmaceutical Preparations; Pharmacology; Phase; Phase III Clinical Trials; Population; Populations at Risk; Positioning Attribute; Pregnant Women; Prevalence; Prevention; Prevention trial; Protocols documentation; Province; Public Health; Race; Randomized; Regimen; Reporting; Research; Research Infrastructure; Research Priority; Research Project Grants; Resistance; South Africa; Tuberculosis; Tuberculosis Vaccines; Twin Multiple Birth; Universities; Vaccines; antiretroviral therapy; bactericide; base; burden of illness; clinical care; clinical research site; co-infection; design; improved; innovation; medical specialties; mycobacterial; neonate; neurodevelopment; novel; premature; prevent; safety study; treatment effect; treatment trial; trial design; tuberculosis drugs; tuberculosis treatment; vaccination against tuberculosis; vaccination strategy; vaccine trial

DESCRIPTION (provided by the applicant): Our overall objective is to provide safe, effective, practical family-centered and integrated prevention, treatment and cure for HIV, TB and other comorbidities in individuals of all races, ages and gender, continuously refined through quality research, innovation and implementation. HIV/AIDS and TB are major global public health problems. South Africa has the highest population prevalence of HIV infection globally and the highest incidence in the world, with >60% of TB cases also HIV-infected. The SUN-CTU is located at the Faculty of Medicine and Health Sciences in urban Cape Town, Western Cape Province of South Africa, an epicenter of these twin epidemics, serving a population of approximately 2.5 million. SUN-CTU combines excellence in research and clinical care with a high prevalence of HIV and TB and populations accessed through 3 closely linked Clinical Research Sites (CRSs) with complementary research focus, strategically situated satellites and proven capacity for a broad spectrum of research. SUN-CTU has a strong family-centered approach, focusing on HIV- and TB-related research and care to large at-risk populations, spanning low birth weight and premature neonates, infants, children, adolescents and adults of all ages. The proposed well-integrated SUN-CTU is a pluripotent network expansion of an existing smaller CTU, at the Children's Infectious Diseases Clinical Research Unit (KID-CRU), focused on IMPAACT network activities. SUN-CTU has already demonstrated considerable capacity to conduct multiple clinical research projects through NIAID and other funding sources, and is particularly well aligned for participation in the IMPAACT, ACTG and HPTN networks. RELEVANCE: South Africa-has a high population prevalence of HIV and TB infection, with >60% of TB cases also HIV infected. The SUN-CTU comprises 3 pluripotent CRSs with complementary research focus and a strong family-centered approach, focusing on HIV- and TB-related research and care to large at-risk populations, spanning low birth weight and premature neonates, infants, children, adolescents and adults of all ages.

描述（由申请人提供）：我们的总体目标是为所有种族、年龄和性别的个体提供安全、有效、实用的以家庭为中心的综合预防、治疗和治愈艾滋病毒、结核病和其他合并症的方法，并通过高质量的研究、创新和实施不断完善。艾滋病毒/艾滋病和结核病是主要的全球公共卫生问题。南非是全球艾滋病毒感染率最高的国家，也是世界上发病率最高的国家，超过60%的结核病病例也是艾滋病毒感染者。SUN-CTU位于南非西开普省城市开普敦的医学和健康科学学院，这两种流行病的中心，为大约250万人口提供服务。SUN-CTU将卓越的研究和临床护理与艾滋病毒和结核病的高流行率以及通过3个密切相关的临床研究中心（CRS）获得的人口相结合，这些临床研究中心具有互补的研究重点，战略卫星和广泛的研究能力。SUN-CTU有一个强有力的以家庭为中心的方法，重点是艾滋病毒和结核病相关的研究和护理的大型高危人群，包括低出生体重和早产儿，婴儿，儿童，青少年和所有年龄段的成年人。拟议的集成良好的SUN-CTU是一个多能网络扩展现有的较小的CTU，在儿童传染病临床研究单位（KID-CRU），专注于IMPAACT网络活动。SUN-CTU已经证明了通过NIAID和其他资金来源进行多个临床研究项目的相当大的能力，并且特别适合参与IMPAACT，ACTG和HPTN网络。 相关性：南非-艾滋病毒和结核病感染的人口流行率很高，超过60%的结核病病例也感染了艾滋病毒。SUN-CTU由3个多能CRS组成，具有互补的研究重点和强有力的以家庭为中心的方法，重点是艾滋病毒和结核病相关的研究和护理大量高危人群，包括低出生体重和早产儿，婴儿，儿童，青少年和所有年龄段的成年人。