Topical Silver Sulfadiazine Formulations with Improved Efficacy and Toxicity Prof

说明(申请人提供)：磺胺嘧啶银(SSD)是世界上使用最广泛的局部抗菌剂，虽然对多种病原体有效，但已被证明可以延缓伤口愈合。将SSD制成乳膏和凝胶，并加入天然成分添加剂，已被证明显著降低了该制剂的毒性，改善了SSD的溶解性，并提高了该药物对几种主要烧伤病原体的疗效。拟议研究的主要具体目标包括在不同浓度的天然添加剂的乳膏和凝胶制剂中制备和配制/加工SSD，测定抗菌效果，细胞相容性，以及在大鼠感染烧伤创面模型中的评估。建议的治疗方法的主要目标是：1)消除感染，2)促进愈合，3.减少总体炎症。这种创新和合理的改进局部抗菌疗法的方法是建立在几项不同研究的基础上的，这些研究揭示了这种改进和普遍应用的疗法有希望的生物适用属性。该项目的最终目标是使一种或多种新型杀微生物剂的开发进入下一阶段，这些新型杀菌剂将用于治疗烧伤创面。

DESCRIPTION (provided by applicant): Silver Sulfadiazine (SSD) is the most widely used topical antimicrobial agent in the world and while effective against a wide variety of pathogens, i has been shown to delay wound healing. Formulation of SSD into creams and gels with the inclusion of a naturally-occurring component additive has been shown to significantly lower the toxicity of the formulation, improve the solubility of SSD, and improve the efficacy of the drug against several leading burn pathogens. The major specific aims of the proposed research involve the preparation & formulation/processing of the SSD in cream and gel formulations with varying concentrations of the naturally-occurring additive, determination of antimicrobial efficacy, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall inflammation. This innovative and rational approach to an improved topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of this improved and commonly applied therapy. The end- goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds.