Development of postural control variability and preferential looking behavior in

姿势控制变异性和偏好观看行为的发展

• 批准号: 8902219
• 负责人: Anastasia Kyvelidou
• 金额: $ 19.47万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8902219
• 关键词: Address; Affect; Age; Age-Months; Attention; Autistic Disorder; Behavior; Cerebral Palsy; Child; Complex; Detection; Development; Diagnosis; Disease; Early Diagnosis; Early Intervention; Evaluation; Exhibits; Face; Goals; Health system; Human; Incidence; Infant; Infant Behavior; Infant Development; Interview; Investigation; Knowledge; Language Development; Learning; Life; Link; Maintenance; Measures; Methods; Modification; Motor; Movement; Musculoskeletal Equilibrium; Neurodevelopmental Disorder; Parents; Pattern; Perception; Population; Premature Infant; Protocols documentation; Quality of life; Risk; Services; Shapes; Siblings; Social Development; Stereotyping; System; Therapeutic; Time; Toddler; Visual; autism spectrum disorder; autistic children; cognitive development; cohort; gaze; improved; motor control; neglect; preference; prevent; response; skills; social; social communication; social communication impairment; tool; visual process; visual processing

The increasing occurrence of autism spectrum disorders (ASD) creates an imperative need for clinicians to identify as early as possible ASD related deficits in order for these children to receive access to early intervention services and possibly a greater chance to improve quality of life. Early signs of ASD related deficits may first become noticeable within the development of the motor system, since it may affect object exploration skills, learning and subsequently cognitive, language and social development. Currently, the average age of ASD diagnosis is around three years even though a reliable and stable diagnosis can be made at around 24 months. However, signs of atypical behavior have been documented retrospectively even earlier by parents of children with autism. It has been suggested that earty postural development as well as gaze behavior could be a useful marker of developmental disruption in children with ASD. Examination of the development of postural control variability in the first year of life could be a valuable tool in discriminating infants with typical development from infants with ASD, similar to what it has been shown in preterm infants and infants at risk for cerebral palsy. In addition, many children with autism engage in a variety of repetitive behaviors and often prefer to attend to visual repetitions. Recently, a very simple method, the preference looking paradigm, has been utilized successfully in toddlers as young as 14 months for identification of ASD but not in younger infants. Therefore, the purpose of this study is to investigate the development of postural control variability and gaze behavior in typically developing infants and infant at nsk for ASD during the first year of life and how these behaviors correlate with measures of social and communication development and with later presence of diagnosis for ASD. Identifying early motor and preferential looking differences in typically developing infants and infants at risk for ASD may allow for a) a greater understanding of the underlying motor and visual processes, b) the development of an earty detection paradigm for autism, and c) the advancement of foundational knowledge from which treatments for autism may be developed.

越来越多的自闭症谱系障碍(ASD)为临床医生创造了迫切的需求 尽早确定与自闭症相关的缺陷，以便这些儿童能够及早获得 干预服务，并可能有更大的机会提高生活质量。与ASD相关的早期症状 缺陷可能首先在马达系统的发展中变得明显，因为它可能会影响物体 探索技能、学习以及随后的认知、语言和社会发展。目前， ASD的平均诊断年龄约为三年，尽管可靠和稳定的诊断可以 在大约24个月的时候制作。然而，非典型行为的迹象甚至被追溯地记录在案 更早的时候，自闭症儿童的父母。有人认为，早期的姿势发育以及 凝视行为可能是ASD儿童发育障碍的一个有用的标志。考试的结果 出生第一年的姿势控制变异性的发展可能是一个有价值的辨别工具 ASD婴儿的典型发育，与早产儿相似 以及有患脑瘫风险的婴儿。此外，许多患有自闭症的儿童会进行各种重复的 而且通常更喜欢注意视觉上的重复。最近，一种很简单的方法，偏爱 LOOK范式已成功地在14个月大的幼儿中用于ASD的鉴定 但在较小的婴儿中则不是。因此，本研究的目的是探讨体态的发展。 在NSK的ASD的第一个阶段，控制典型发育婴儿和婴儿的可变性和注视行为 以及这些行为如何与衡量社会和通信发展和 后来出现ASD的诊断。识别早期运动和偏爱看起来的差异 通常情况下，发育中的婴儿和有ASD风险的婴儿可以使a)更好地了解 基础运动和视觉过程，b)自闭症早期检测范例的发展，以及c) 基础知识的进步，自闭症的治疗可以从这些基础知识发展而来。