Anthelmintics: From discovery of new drugs to modes of action and resistance

驱虫药：从新药的发现到作用方式和耐药性

• 批准号: 8646022
• 负责人: Adrian J Wolstenholme
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-02 至 2015-01-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8646022
• 关键词: Adult; Agreement; Air; American; Animals; Anthelmintics; Appearance; Applications Grants; Area; Ascaris lumbricoides; Asia; Belief; Cancer Etiology; Canis familiaris; Cestoda; Collaborations; Communication; Communities; Country; Development; Disease; Drug resistance; Drug usage; Economic Development; Effectiveness; Ensure; Equus caballus; Farming environment; Filarial Elephantiases; Health; Helminths; Home environment; Hookworms; Human; Human Development; Incidence; Infection; Infection Control; Infection prevention; International; Journals; Knowledge; Laboratory Research; Lead; Learning; Link; Livestock; Loa loa; London; Measures; Medical; Medicine; Methods; Minor; Nematoda; Ocular Onchocerciasis; Parasites; Pathway interactions; Pharmaceutical Preparations; Platyhelminths; Population; Praziquantel; Production; Prophylactic treatment; Public Health; Publications; Publishing; Recording of previous events; Research Personnel; Resistance; Risk; San Francisco; Schistosoma; Schistosomiasis; Science; Scientist; Series; Soil; Time; Toxocara; Trichocephalus trichiura; Trichuris trichiura infection; Tropical Disease; United States; Vaccines; Veterinary Medicine; Work; World Health Organization; base; combat; commercialization; companion animal; disease transmission; disorder control; drug discovery; experience; farmer; foodborne; improved; interdisciplinary collaboration; meetings; neglect; novel; operation; programs; public health relevance; success; symposium

DESCRIPTION (provided by applicant): R13 Conference: 'Anthelmintics: Laboratory Research, from discovery of new drugs to modes of action and resistance to existing ones'. Parasitic helminths, which include roundworms (nematodes), flatworms (trematodes) and tapeworms (cestodes), cause many of the most prevalent Neglected Tropical Diseases (NTDs) and many serious infections of animals. The nematodes include the soil-transmitted helminths (STH), which comprise Ascaris lumbricoides, the hookworms and Trichuris trichiura, which together are estimated to infect about one-third of the world's population, and the filarial nematodes which cause lymphatic filariasis and river blindness, diseases which threaten nearly 200 million people. The trematodes include the schistosomes, which infect 300 million people, and the food-borne trematodes, a group of parasites that are one of the leading causes of cancer in S.E. Asia. Infections of animals with related cause major production losses to livestock farmers and seriously impact the health of companion animals, such as dogs and horses. In all cases, prophylaxis, treatment and control of these infections are based largely on anthelmintic drugs, and the major efforts to reduce and eliminate some of the human parasites are entirely dependent on mass drug administration programs. Lymphatic filariasis has been targeted for global elimination by 2020 and regional elimination of schistosomiasis and river blindness is planned for 2015 or 2020, depending on the region. It is widely accepted that new anthelmintic drugs are required for both human and animal use, especially if these ambitious targets are to be met. Most of the drugs currently used in human medicine were originally developed for veterinary use, and their widespread application in animal health has led to serious problems of drug resistance; the appearance of widespread anthelmintic resistance in human parasites could be disastrous for international efforts to combat NTDs. The history of anthelmintic drug discovery and use clearly shows the need for dialogue between medical and veterinary parasitologists in order to ensure that elimination and control of these diseases proceeds as well as possible. Our conference is planned to take place in San Francisco in February 2014, at the Fort Mason Conference Center. San Francisco is home to several leading groups in anthelmintic drug discovery and was chosen because of its excellent national and international air connections. The meeting will have open registration for national and international attendees, and we estimate that about 100 will attend. We will consider the meeting a success if it results in the formation of new international collaborations and increased links and co-operation between industrial and academic researchers. We intend to produce 5-10 authoritative review articles in an Open Access scientific journal following the meeting.

描述（由申请人提供）：R13会议：“驱虫药：实验室研究，从新药的发现到作用模式和对现有药物的抗性”。 寄生蠕虫，包括蛔虫（线虫）、扁虫（吸虫）和绦虫（绦虫），引起许多最普遍的被忽视的热带病（NTD）和许多严重的动物感染。线虫包括土传蠕虫（STH），其中包括蛔虫、钩虫和鞭虫，估计它们共同感染了世界上约三分之一的人口，以及引起淋巴丝虫病和河盲症的丝虫线虫，这些疾病威胁着近2亿人。吸虫包括感染3亿人的寄生虫，以及食源性吸虫，这是一组寄生虫，是S.E.癌症的主要原因之一。亚洲相关动物的感染给畜牧业者造成重大生产损失，并严重影响伴侣动物（如狗和马）的健康。在所有情况下，这些感染的预防、治疗和控制主要基于驱虫药，减少和消除一些人体寄生虫的主要努力完全依赖于大规模药物管理计划。淋巴丝虫病的目标是到2020年在全球消除，并计划在2015年或2020年根据区域情况在区域一级消除血吸虫病和河盲症。人们普遍认为，人类和动物都需要新的驱虫药，特别是如果要实现这些雄心勃勃的目标。目前用于人类医学的大多数药物最初是为兽医用途而开发的，它们在动物健康中的广泛应用导致了严重的耐药性问题;人类寄生虫对驱虫药的广泛耐药性的出现可能对国际上防治NTD的努力造成灾难性影响。驱虫药的发现和使用的历史清楚地表明，医学和兽医寄生虫学家之间的对话，以确保消除和控制这些疾病的进展以及可能的必要性。 我们的会议计划于2014年2月在弗朗西斯科的梅森堡会议中心举行。旧金山弗朗西斯科是几个领先的驱虫药发现小组的所在地，并因其良好的国内和国际航空连接而被选中。 会议将对国内和国际与会者开放注册，我们估计约有100人将出席。如果会议能促成新的国际合作，并加强工业界和学术界研究人员之间的联系和合作，我们将认为会议是成功的。我们打算在会后在开放获取科学期刊上发表5-10篇权威评论文章。