The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit

FIOCRUZ 治疗和预防艾滋病毒/艾滋病临床试验单位

• 批准号: 8609412
• 负责人: BEATRIZ GRINSZTEJN
• 金额: $ 199.56万
• 依托单位: FUNDACAO OSWALDO CRUZ
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-15 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609412
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Achievement; Affect; Area; Behavioral; Brazil; Caring; Clinical Trials; Clinical Trials Unit; Collaborations; Communication; Communities; Comorbidity; Developing Countries; Drug Formulations; Epidemic; Foundations; Goals; HIV; HIV Infections; HIV prevention trials network; Hepatitis C; Individual; Infection; Institutes; Intervention; Latin America; Leadership; Microbicide Trials Network; Minority; Participant; Persons; Population; Poverty; Prevention; Prophylactic treatment; Regimen; Research; Research Design; Research Infrastructure; Research Personnel; Risk; Safety; Site; Technology; Therapeutic; Tuberculosis; Woman; base; clinical research site; fight against; improved; insight; men who have sex with men; multidisciplinary; novel; novel diagnostics; novel therapeutic intervention; novel therapeutics; prevent; public health research; rectal microbicide; transgender; treatment strategy

DESCRIPTION (provided by the applicant): The Oswaldo Cruz Foundation (FIOCRUZ) Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials), is a multidisciplinary, integrated research center based in Rio de Janeiro, Brazil that is partnered with the Institute de Pesquisa Clinica Evandro Chagas Clinical Research Site (IPEC CRS), Together the FioTrials CTU and IPEC CRS provide care for both "at-risk" and HIV infected persons and cater to the needs of certain disenfranchised populations, including men who have sex with men (MSM), transgender women, racial minorities, women, and those who are poverty stricken and/or uneducated. The FioTrials CTU and IPEC CRS have unique strengths to offer the AIDS Clinical Trials Group (ACTG), HIV Prevention Trials Network (HPTN) and Microbicide Trials Network (MTN), including a cadre of leading researchers; a partnership with FIOCRUZ, an internationally-recognized governmental organization dedicated to public health research; and a participant population that compliments the scientific agendas of each network. The goal of our research is to 1) evaluate and implement integrated strategies (therapeutic and behavioral) to prevent HIV acquisition in MSM, transgender women and women; 2) evaluate the safety, efficacy and utility of rectal microbicides for our MSM population; 3) evaluate novel diagnostics, technologies, prevention and treatment interventions for tuberculosis in HIV co-infected individuals; 4) evaluate novel treatment strategies for hepatitis C, particularly for those with HI co-infection; and 5) assess novel therapeutics and improve existing HIV treatment strategies and prevent co-morbidities. Achievement of these objectives will be attributed to the outstanding infrastructure of the FioTrials CTU, its CRS and its community-focused research strategies.

描述（申请人提供）：奥斯瓦尔多·克鲁兹基金会（FIOCRUZ）艾滋病毒/艾滋病治疗和预防临床试验股（FioTrials）是一个多学科的综合研究中心，位于巴西里约热内卢，与Institute de Pesquisa Clinica Evandro Chagas临床研究中心合作FioTrials CTU和IPEC CRS共同为“高危”和艾滋病毒感染者提供护理，并满足某些被剥夺公民权的人群的需求，包括男男性行为者，变性妇女、少数民族、妇女以及贫困和/或未受教育的人。FioTrials CTU和IPEC CRS具有独特的优势，可为艾滋病临床试验组（ACTG），艾滋病毒预防试验网络（HPTN）和杀微生物剂试验网络（MTN）提供服务，包括领先的研究人员骨干;与FIOCRUZ（一个致力于公共卫生研究的国际公认的政府组织）建立伙伴关系;以及参与人口，以补充每个网络的科学议程。我们的研究目标是：1）评估和实施综合战略（治疗和行为），以防止艾滋病毒感染的男男性行为者，变性妇女和妇女; 2）评估安全性，有效性和实用性的直肠杀微生物剂为我们的男男性行为者人群; 3）评估新的诊断，技术，预防和治疗干预措施，结核病的艾滋病毒合并感染的个人; 4）评估丙型肝炎的新治疗策略，特别是对于那些HI合并感染的患者;和5）评估新的治疗方法并改善现有的HIV治疗策略和预防合并症。这些目标的实现将归功于FioTrials CTU，其CRS及其以社区为中心的研究战略的出色基础设施。