Comorbidity: Substance Use Disorders and Other Psychiatric Conditions

描述（由申请人提供）：长期目标：在NIDA资助的培训赠款的当前组合中，没有一个将科摩罗作为主要重点。考虑到物质使用障碍（SUD）与其他精神疾病和健康状况（例如糖尿病）的共同发生率，以及SUD或共病障碍在常规治疗环境中可能未得到治疗或未得到治疗的程度，这是惊人的。必须加强研究专门知识，以改进诊断、治疗和预防战略。拟议的计划将培养一批在并发症机制、前因和相关因素、诊断以及心理社会和药理干预方面具有研究专长的科学家。组成部分的目标是为每位学员提供共病研究的工作知识，包括：（a）从早期临床试验到基于社区的预防性研究的转化科学;（B）跨人群和种族和文化群体（例如美国印第安人，苗族，索马里人）的共病有效研究策略。完成程序功能将利用（a）教师专业知识的频谱提供跨多个领域的指导，（B）跨培训计划和部门的整合。关键要素：（1）具有不同专业知识的科学家和临床医生以及核心内部咨询小组的参与。原发部位（4名博士后实习生，每人2年）是精神病学系（UMN双城）和生物行为健康与人口科学（UMN杜卢斯），由心理学系（UMTC）和其他UMN实体的支持;（2）招聘，包括代表性不足的群体外展，严格筛选博士和博士候选人与SUD和科摩罗作为主要职业重点;（3）与跨学科指导小组一起进行培训（4）具有明确里程碑的正式培训计划，包括第一年开始的NIH应用程序的受训者开发;（5）积极的研究，研讨会，教学课程工作，讲习班，以及管理，道德和监管专业知识的发展;（6）动态的方案管理，包括监测和改进，沿着问题解决，以及在完成后与受训者继续接触;（7）每年召集外部咨询小组。资源：导师资金来源包括NIH研究所，NSF，明尼苏达医学基金会和制药行业。关键人员和主要导师是拥有重要资源的诊所、中心或部门的主管。该计划侧重于实习生在SUD与精神疾病（焦虑，ADHD，边缘，饮食，抑郁，精神分裂症，创伤）共同发生的专业知识。

DESCRIPTION (provided by applicant): Long-term goals: Among the current portfolio of NIDA funded training grants, none have comorbidity as a primary focus. This is striking given co-occurrence prevalence of Substance Use Disorders (SUD) with other psychiatric conditions and health conditions (e.g. diabetes), and the extent to which either SUD or the comorbid disorder can go under- or untreated in conventional treatment settings. Enhancing research expertise to improve diagnostic, treatment and prevention strategies is essential. The proposed program will develop a cadre of scientists with research expertise in comorbidity mechanisms, antecedents and correlates, diagnostics, and psychosocial and pharmacological interventions. Component objectives are to provide each trainee with a working knowledge of comorbidity research including: (a) translational science from Early Phase Clinical Trials to Community Based Participatory Research perspectives; (b) effective research strategies for comorbid conditions across populations and ethnic and cultural groups (e.g. American Indian, Hmong, Somali). Accomplishing programmatic features will capitalize on (a) the spectrum of faculty expertise providing mentoring across multiple areas, and (b) integration across training programs and departments. Key Elements: (1) Involvement of scientists and clinicians with diverse expertise and a core internal advisory group. Primary sites (4 postdoctoral trainees, 2 yrs each) are the Departments of Psychiatry (UMN Twin Cities) and Biobehavioral Health & Population Science (UMN Duluth), supported by the Psychology Department (UMTC) and other UMN entities; (2) Recruitment, including under represented group outreach, of rigorously screened PhD and MD candidates with SUD and comorbidity as primary career focus; (3) Training with an interdisciplinary mentoring team (primary & 2 secondary mentors) with complementary expertise; (4) Formal training plans with clear milestones including trainee development of an NIH application initiated in Year 1; (5) Active research, seminars, didactic course work, workshops, and development of management, ethics, and regulatory expertise; (6) Dynamic program administration entailing monitoring with enhancements and problem resolution along with continued contact with trainees after completion and; (7) Annually convened external advisory group. Resources: Mentor funding sources include NIH Institutes, NSF, Minnesota Medical Foundation, and pharmaceutical industry. Key Personnel and Primary Mentors are directors of clinics, centers, or departments with significant resources. The program focuses on trainee expertise in SUD co-occurring with psychiatric disorders (Anxiety, ADHD, Borderline, Eating, Depression, Schizophrenia, Trauma).