Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network

尤尼斯·肯尼迪·施赖弗 (Eunice Kennedy Shriver) NICHD 母胎医学单位网络

• 批准号: 8838835
• 负责人: EDWARD K CHIEN
• 金额: $ 30.93万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838835
• 关键词: Abbreviations; Adherence; Adrenal Cortex Hormones; Affect; Antibiotics; Bacterial Vaginosis; Birth; Calcium; Caregivers; Cervical; Cervix Uteri; Clinical; Clinical Research; Clinical Sciences; Collaborations; Conduct Clinical Trials; Development; Discipline of obstetrics; Environment; Faculty; Family; Fetal Growth Retardation; Funding; Genomics; Gestational Diabetes; Health; High-Risk Pregnancy; Home environment; Hospitals; Hyperglycemia; Hypothyroidism; Infant; Intervention; Lead; Leadership; Length; Life; Magnesium Sulfate; Medical center; Morbidity - disease rate; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Neonatology; Observational Study; Ohio; Omega-3 Fatty Acids; Outcome; Pediatric Hospitals; Performance; Perinatal; Perinatal Infection; Play; Population Heterogeneity; Pre-Eclampsia; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Premature Labor; Premature Rupture Fetal Membranes; Prevention; Principal Investigator; Procedures; Progesterone; Proteomics; Publications; Pulse Oximetry; Qualifying; Recording of previous events; Reporting; Reproductive Biology; Research; Research Infrastructure; Research Personnel; Risk; Role; Steroids; Surrogate Markers; Technology; Time; Translational Research; Trichomonas vaginalis; Triplet Multiple Birth; Twin Multiple Birth; Ultrasonography; United States; United States National Institutes of Health; Universities; University Hospitals; Uterine Monitoring; Woman; adverse outcome; design; experience; fetal; fetal fibronectin; fetal medicine; follow-up; high risk; improved; infant outcome; interest; intrapartum; multidisciplinary; neuroprotection; prenatal; prevent; success; tool

DESCRIPTION (provided by applicant): Obstetric practices, evaluative tools, and treatments have been sometimes passed down by tradition or introduced without rigorous study to evaluate their impact on maternal, fetal, and/or neonatal outcomes. Long-term maternal and infant outcomes are particularly understudied, and surrogate markers of morbidity are commonly substituted in studies of smaller size. The impact of pregnancy complications can be devastating, affecting decades of life. The health and financial impacts of adverse maternal and infant outcomes on the family are potentially staggering. With millions of births in the United States each year, even uncommon complications can have a profound societal impact. Since its inception, the Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) research network has conducted clinical trials and observational studies that have brought important understanding regarding prediction and prevention of preterm birth (Preterm Prediction Study, 17-OH progesterone in singletons, twins, and triplets, omega-3 supplements, antibiotics for asymptomatic bacterial vaginosis and T. Vaginalis), treatments for those at imminent risk (antibiotics for preterm labor and premature rupture of the membranes, repeated antenatal corticosteroids, magnesium sulfate neuroprotection), cesarean delivery and VBAC, prevention of preeclampsia, and treatment of gestational diabetes, among others. This network played a key role in evaluating technologies used in obstetric practice (ultrasound cervical length, fetal fibronectin, home uterine monitoring, fetal pulse oximetry). In this application, we demonstrate that the Department of Reproductive Biology at Case Western Reserve University (CASE) investigators have the ability to conduct collaborative research, and have successfully participated in and are qualified to continue in the MFMU network. Our investigators have strong backgrounds in clinical and multicenter studies, those involving neonatal and long term infant follow-up, and in the above listed network studies. CASE investigators provide leadership in network study development and administrative committees necessary to study completion and dissemination of their results. There is a strong administrative and research infrastructure to support the MFMU network, including the CASE-Clinical & Translational Science Collaborative. CASE offers the strengths needed to successfully lead and participate in NICHD-MFMU network research which will directly influence obstetric practice and improve pregnancy outcomes nationally and internationally.

描述（由申请人提供）：产科实践、评估工具和治疗有时通过传统传承下来，或在没有严格研究的情况下引入，以评估其对孕产妇、胎儿和/或新生儿结局的影响。长期母婴结局的研究尤其不足，在较小规模的研究中，发病率的替代标志物通常被替代。妊娠并发症的影响可能是毁灭性的，影响几十年的生活。不利的母婴结果对家庭的健康和经济影响可能是惊人的。美国每年有数百万新生儿，即使是不常见的并发症也会产生深远的社会影响。自成立以来，Eunice Kennedy Shriver NICHD母胎医学单位（MFMU）研究网络已经进行了临床试验和观察性研究，这些研究带来了关于早产预测和预防的重要理解（早产预测研究，单胎，双胞胎和三胞胎中的17-OH孕酮，omega-3补充剂，用于无症状细菌性阴道病的抗生素和T。阴道炎），治疗那些有迫在眉睫的风险（抗生素早产和胎膜早破，重复产前皮质类固醇，硫酸镁神经保护），剖腹产和VBAC，预防先兆子痫，治疗妊娠糖尿病等。该网络在评估产科实践中使用的技术（超声宫颈长度、胎儿纤维连接蛋白、家庭子宫监测、胎儿脉搏血氧测定）方面发挥了关键作用。 在本申请中，我们证明了凯斯西储大学（CASE）生殖生物学系的研究人员有能力进行合作研究，并成功参与并有资格继续在MFMU网络中。我们的研究者在临床和多中心研究、涉及新生儿和长期婴儿随访的研究以及上述网络研究方面具有强大的背景。案例研究者在网络研究开发和必要的行政委员会提供领导，以研究完成和传播他们的结果。有一个强大的行政和研究基础设施，以支持MFMU网络，包括案例临床和转化科学协作。CASE提供成功领导和参与NICHD-MFMU网络研究所需的优势，这将直接影响产科实践并改善国内和国际的妊娠结局。