Preclinical Development of HIV-1 Vif Antagonists - Core B

HIV-1 Vif 拮抗剂的临床前开发 - 核心 B

• 批准号: 8904727
• 负责人: Agneta von Gegerfelt
• 金额: $ 9.09万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904727
• 关键词: Administrator; Agreement; Antiviral Agents; Attenuated; Cell Line; Cells; Communicable Diseases; Communication; Data; Defective Viruses; Development; Doctor of Philosophy; Drug Kinetics; Ensure; Evaluation; Exercise; Exhibits; Funding; Goals; Grant; HIV-1; In Vitro; Individual; Industry; Inhibitory Concentration 50; Institution; Instruction; Intellectual Property; Lead; Lymphoid; Macaca; Modeling; Monkeys; Mutation; Pathogenicity; Penetration; Peripheral; Persons; Phenotype; Plasma; Preparation; Progress Reports; Publications; Reagent; Research; Research Personnel; Resistance; Resistance profile; Resources; SIV; Serial Passage; Series; Site Visit; Staging; Toxic effect; United States National Institutes of Health; Variant; Viral; Virus; Water; analog; cellular targeting; data exchange; data sharing; design; drug discovery; in vivo; inhibitor/antagonist; insight; macrophage; meetings; mutant; neuroAIDS; novel; pre-clinical; programs; resistance mutation; response; small molecule; success; vif Genes; viral RNA

Our goal of identifying novel antagonists of HlV-1 vif involves the efforts of four investigators at four different institutions. The research plan requires close communication between these groups, rapid exchange of data, research materials and reagents as well the ability to solicit input from the Scientific Advisory Board (SAB) and act on that input. These activities will be coordinated by the Administrative Core. The major functions of the Core will include: Coordinate biannual, in-person meetings between project leaders and the SAB in order to overview progress, set milestones and action items for the individual projects. Maintain budgetary oversight for the individual research components and, if necessary reallocate resources if recommended by the SAB. Promote continuous dialog between investigators engaged in the project through teleconferencing. Coordinate data sharing and the exchange of materials at different stages in the project. Coordinate preparation of progress reports to the NIH as well as an annual NIH site-visit. Coordinate the presentation of research findings at scientific meetings and publication of research findings.. Serve as an intermediary with the Commercial Ventures and Intellectual Property office ofthe participating Institutions as well as for any issues that arise through intellectual property agreements. Mario Stevenson, Ph.D. will serve as Director ofthe Administrative Core and will be assisted by Maria Pieiga who, as Administrator ofthe Division of Infectious Diseases, has extensive expertise in the oversight of NIH and Industry-funded projects.

我们的目标是鉴定新的hcv -1 vif拮抗剂，涉及四个不同机构的四位研究人员的努力。研究计划要求这些小组之间密切沟通，迅速交换数据、研究材料和试剂，以及能够征求科学咨询委员会（SAB）的投入并根据这些投入采取行动。这些活动将由行政核心协调。核心的主要职能包括：